BAKER BROS. ADVISORS LP Q4 2023 Filing
Filed February 14, 2024
Portfolio Value
$8.8B
Holdings
84
Report Date
Q4 2023
Filing Type
13F-HR
All Holdings (84 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | INCYIncyte Corporation | 36,179,122 | $2.3B | 25.85% | |
| 2 | ONCBeiGene, Ltd. | 10,568,897 | $1.9B | 21.69% | |
| 3 | ACADACADIA Pharmaceuticals Inc. | 42,864,612 | $1.3B | 15.27% | |
| 4 | MDGLMadrigal Pharmaceuticals, Inc. | 1,969,798 | $455.8M | 5.19% | |
| 5 | RYTMRhythm Pharmaceuticals, Inc. | 6,398,365 | $294.1M | 3.35% | |
| 6 | MRTXEURMirati Therapeutics, Inc. | 4,121,440 | $242.1M | 2.76% | |
| 7 | IMCRImmunocore Holdings plc | 2,520,731 | $172.2M | 1.96% | |
| 8 | KYMRKymera Therapeutics, Inc. | 5,995,928 | $152.7M | 1.74% | |
| 9 | RVMDRevolution Medicines, Inc. | 5,148,657 | $147.7M | 1.68% | |
| 10 | —Invitae Corporation | 300,000,000 | $131.2M | 1.49% | |
| 11 | ABCLAbCellera Biologics Inc. | 22,909,753 | $130.8M | 1.49% | |
| 12 | ROIVRoivant Sciences Ltd. | 7,593,024 | $85.3M | 0.97% | |
| 13 | REPLReplimune Group, Inc. | 9,545,336 | $80.5M | 0.92% | |
| 14 | TRDAEntrada Therapeutics, Inc. | 4,865,819 | $73.4M | 0.84% | |
| 15 | RAREUltragenyx Pharmaceutical Inc. | 1,466,547 | $70.1M | 0.80% | |
| 16 | CERE1EURCerevel Therapeutics Holdings, Inc. | 1,600,000 | $67.8M | 0.77% | |
| 17 | IMTXImmatics N.V. | 5,838,853 | $61.5M | 0.70% | |
| 18 | BCRXBioCryst Pharmaceuticals, Inc. | 10,126,176 | $60.7M | 0.69% | |
| 19 | ARGXargenx SE | 151,215 | $57.5M | 0.65% | |
| 20 | DNLIDenali Therapeutics Inc. | 2,607,196 | $56.0M | 0.64% | |
| 21 | AKROAkero Therapeutics, Inc. | 2,368,378 | $55.3M | 0.63% | |
| 22 | KODKodiak Sciences Inc. | 17,310,490 | $52.6M | 0.60% | |
| 23 | KNSAKiniksa Pharmaceuticals, Ltd. | 2,809,577 | $49.3M | 0.56% | |
| 24 | XENEXenon Pharmaceuticals Inc. | 993,679 | $45.8M | 0.52% | |
| 25 | PRLDPrelude Therapeutics Inc. | 10,123,824 | $43.2M | 0.49% | |
| 26 | CERSCerus Corporation | 19,477,339 | $42.1M | 0.48% | |
| 27 | NRIXNurix Therapeutics, Inc. | 3,882,125 | $40.1M | 0.46% | |
| 28 | AVTEAerovate Therapeutics, Inc. | 1,680,517 | $38.0M | 0.43% | |
| 29 | IDYAIDEAYA Biosciences, Inc. | 1,062,123 | $37.8M | 0.43% | |
| 30 | EWTXEdgewise Therapeutics, Inc. | 3,112,786 | $34.1M | 0.39% | |
| 31 | SERASera Prognostics, Inc. | 5,434,399 | $32.5M | 0.37% | |
| 32 | BCYCBicycle Therapeutics plc | 1,790,390 | $32.4M | 0.37% | |
| 33 | 1K0IGM Biosciences, Inc. | 3,691,011 | $30.7M | 0.35% | |
| 34 | BMEABiomea Fusion, Inc. | 2,108,949 | $30.6M | 0.35% | |
| 35 | GLUEMonte Rosa Therapeutics, Inc. | 4,916,095 | $27.8M | 0.32% | |
| 36 | VERVVerve Therapeutics, Inc. | 1,691,530 | $23.6M | 0.27% | |
| 37 | KRYSKrystal Biotech, Inc. | 169,934 | $21.1M | 0.24% | |
| 38 | GRCLGracell Biotechnologies Inc. | 2,080,000 | $20.9M | 0.24% | |
| 39 | IMVTImmunovant, Inc. | 425,009 | $17.9M | 0.20% | |
| 40 | TCRXTScan Therapeutics, Inc. | 2,784,792 | $16.2M | 0.18% | |
| 41 | DAWNDay One Biopharmaceuticals, Inc. | 1,000,000 | $14.6M | 0.17% | |
| 42 | —DBV Technologies S.A. | 14,614,264 | $13.9M | 0.16% | |
| 43 | RLAYRelay Therapeutics, Inc. | 1,160,117 | $12.8M | 0.15% | |
| 44 | SPRYARS Pharmaceuticals, Inc. | 2,006,451 | $11.0M | 0.13% | |
| 45 | STOKStoke Therapeutics, Inc. | 2,030,134 | $10.7M | 0.12% | |
| 46 | TSVT*2seventy bio, Inc. | 2,497,526 | $10.7M | 0.12% | |
| 47 | IM8NInsmed Incorporated | 343,000 | $10.6M | 0.12% | |
| 48 | TCE2Celldex Therapeutics, Inc. | 247,644 | $9.8M | 0.11% | |
| 49 | PRMEPrime Medicine, Inc. | 1,028,466 | $9.1M | 0.10% | |
| 50 | NGNENeurogene Inc. | 453,516 | $8.8M | 0.10% | |
| 51 | ADAPYAdaptimmune Therapeutics plc | 10,969,282 | $8.7M | 0.10% | |
| 52 | SANASana Biotechnology, Inc. | 2,000,000 | $8.2M | 0.09% | |
| 53 | SGMTSagimet Biosciences Inc. | 1,456,518 | $7.9M | 0.09% | |
| 54 | CELCCelcuity Inc. | 535,478 | $7.8M | 0.09% | |
| 55 | —Athira Pharma, Inc. | 3,153,807 | $7.7M | 0.09% | |
| 56 | OPTEYOpthea Limited | 2,588,645 | $7.6M | 0.09% | |
| 57 | TNGXTango Therapeutics, Inc. | 750,000 | $7.4M | 0.08% | |
| 58 | TSHATaysha Gene Therapies, Inc. | 4,004,756 | $7.1M | 0.08% | |
| 59 | HOOKGBPHOOKIPA Pharma Inc. | 8,128,151 | $6.6M | 0.07% | |
| 60 | —Invitae Corporation | 9,274,000 | $6.3M | 0.07% | |
| 61 | MIRMMirum Pharmaceuticals, Inc. | 190,476 | $5.6M | 0.06% | |
| 62 | XNCRXencor, Inc. | 245,431 | $5.2M | 0.06% | |
| 63 | CYPHLeap Therapeutics, Inc. | 1,172,175 | $4.9M | 0.06% | |
| 64 | DSGNDesign Therapeutics, Inc. | 1,500,000 | $4.0M | 0.05% | |
| 65 | TLISTalis Biomedical Corporation | 508,323 | $3.8M | 0.04% | |
| 66 | ISREURPerspective Therapeutics, Inc. | 7,639,703 | $3.1M | 0.03% | |
| 67 | PCVXVaxcyte, Inc. | 48,885 | $3.1M | 0.03% | |
| 68 | PRAXPraxis Precision Medicines, Inc. | 131,533 | $2.9M | 0.03% | |
| 69 | IPSCCentury Therapeutics, Inc. | 797,460 | $2.6M | 0.03% | |
| 70 | —Mersana Therapeutics, Inc. | 1,086,115 | $2.5M | 0.03% | |
| 71 | CMPXCompass Therapeutics, Inc. | 1,557,630 | $2.4M | 0.03% | |
| 72 | 698Achilles Therapeutics plc | 2,102,792 | $1.9M | 0.02% | |
| 73 | KALAKALA BIO, Inc. | 266,613 | $1.9M | 0.02% | |
| 74 | ALGSAligos Therapeutics, Inc. | 2,076,400 | $1.4M | 0.02% | |
| 75 | NVTA1EURInvitae Corporation | 1,764,546 | $1.1M | 0.01% | |
| 76 | PFEPfizer Inc. | 35,000 | $1.0M | 0.01% | |
| 77 | PMVPPMV Pharmaceuticals, Inc. | 322,024 | $998K | 0.01% | |
| 78 | WHWKAadi Bioscience, Inc. | 251,727 | $508K | 0.01% | |
| 79 | TARAProtara Therapeutics, Inc. | 199,671 | $374K | 0.00% | |
| 80 | CABACabaletta Bio, Inc. | 13,331 | $302K | 0.00% | |
| 81 | FHTXFoghorn Therapeutics Inc. | 45,027 | $290K | 0.00% | |
| 82 | BCELAtreca, Inc. | 2,177,499 | $287K | 0.00% | |
| 83 | TYRATyra Biosciences, Inc. | 10,607 | $146K | 0.00% | |
| 84 | SRZNWSurrozen, Inc. | 833,333 | $16K | 0.00% |