BAKER BROS. ADVISORS LP Q4 2018 Filing

Filed February 13, 2019

Portfolio Value

$12.2T

Holdings

93

Report Date

Q4 2018

Filing Type

13F-HR

All Holdings (93 positions)

#StockSharesValue% PortfolioType
1
SGENEURSeattle Genetics, Inc.
51,046,060$2.9T23.68%
2
INCYIncyte Corporation
34,251,607$2.2T17.83%
3
ONCBeiGene, Ltd.
11,959,824$1.7T13.74%
4
ALXNAlexion Pharmaceuticals, Inc.
8,555,894$833.0B6.82%
5
Genomic Health, Inc.
11,744,010$756.4B6.19%
6
BMRNBioMarin Pharmaceutical Inc.
7,589,294$646.2B5.29%
7
ACADACADIA Pharmaceuticals Inc.
39,713,842$642.2B5.26%
8
AMRNAmarin Corporation plc
42,592,824$579.7B4.75%
9
ASNDAscendis Pharma A/S
2,837,352$177.8B1.46%
10
MDGLMadrigal Pharmaceuticals, Inc.
1,169,278$131.8B1.08%
11
HRTXHeron Therapeutics, Inc.
5,018,104$130.2B1.07%
12
BCRXBioCryst Pharmaceuticals, Inc.
15,103,081$121.9B1.00%
13
MRTXEURMirati Therapeutics, Inc.
2,513,462$106.6B0.87%
14
ARGXargenx SE
1,019,557$97.9B0.80%
15
KNSAKiniksa Pharmaceuticals, Ltd.
3,000,000$84.3B0.69%
16
RYTMRhythm Pharmaceuticals, Inc.
2,708,200$72.8B0.60%
17
ARRYEURArray BioPharma Inc.
5,041,696$71.8B0.59%
18
KODKodiak Sciences Inc.
9,145,115$64.9B0.53%
19
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
53,270,000$63.4B0.52%
20
CERSCerus Corporation
10,749,937$54.5B0.45%
21
Spark Therapeutics, Inc.
1,384,130$54.2B0.44%
22
NBIXNeurocrine Biosciences, Inc.
730,355$52.2B0.43%
23
Principia Biopharma Inc.
1,787,807$49.0B0.40%
24
Clementia Pharmaceuticals Inc.
3,724,445$43.8B0.36%
25
NVTA1EURInvitae Corporation
3,902,421$43.2B0.35%
26
GW Pharmaceuticals plc
428,345$41.7B0.34%
27
CBAYUSDCymaBay Therapeutics, Inc.
4,917,700$38.7B0.32%
28
1T7Tricida, Inc.
1,600,000$37.7B0.31%
29
DBV Technologies S.A.
5,509,560$35.4B0.29%
30
Zymeworks Inc.
1,708,472$25.1B0.21%
31
IM8NInsmed Incorporated
1,851,982$24.3B0.20%
32
Aquinox Pharmaceuticals, Inc.
10,934,154$23.6B0.19%
33
Audentes Therapeutics, Inc.
910,463$19.4B0.16%
34
QUREuniQure N.V.
605,000$17.4B0.14%
35
KRYSKrystal Biotech, Inc.
784,674$16.3B0.13%
36
MRUSMerus N.V.
1,160,014$16.2B0.13%
37
Aimmune Therapeutics, Inc.
673,908$16.1B0.13%
38
XNCRXencor, Inc.
440,186$15.9B0.13%
39
SLDBSolid Biosciences Inc.
587,884$15.8B0.13%
40
MyoKardia, Inc.
315,243$15.4B0.13%
41
Abeona Therapeutics Inc.
2,103,164$15.0B0.12%
42
Ra Pharmaceuticals, Inc.
823,113$15.0B0.12%
43
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$14.9B0.12%
44
Idera Pharmaceuticals, Inc.
4,836,237$13.4B0.11%
45
AGLEUSDAeglea BioTherapeutics, Inc.
1,713,604$12.8B0.11%
46
GBYSangamo Therapeutics, Inc.
999,823$11.5B0.09%
47
ContraFect Corporation
7,153,076$10.9B0.09%
48
NVAXNovavax, Inc.
4,718,318$8.7B0.07%
49
TPIVDEURMarker Therapeutics, Inc.
1,500,000$8.3B0.07%
50
Bellicum Pharmaceuticals, Inc.
2,677,818$7.8B0.06%
51
ANABAnaptysBio, Inc.
113,086$7.2B0.06%
52
IFRXInflaRx N.V.
178,987$6.5B0.05%
53
Spring Bank Pharmaceuticals, Inc.
613,144$6.4B0.05%
54
BDQMAlbireo Pharma, Inc.
250,000$6.1B0.05%
55
CPRXCatalyst Pharmaceuticals, Inc.
2,900,000$5.6B0.05%
56
AUTLAutolus Therapeutics plc
156,773$5.1B0.04%
57
HALOHalozyme Therapeutics, Inc.
299,969$4.4B0.04%
58
bluebird bio, Inc.
40,000$4.0B0.03%
59
CRNXCrinetics Pharmaceuticals, Inc.
131,250$3.9B0.03%
60
Forty Seven, Inc.
250,000$3.9B0.03%
61
XLRNAcceleron Pharma Inc.
83,900$3.7B0.03%
62
ASMBAssembly Biosciences, Inc.
148,587$3.4B0.03%
63
VKTXViking Therapeutics, Inc.
425,000$3.3B0.03%
64
Syros Pharmaceuticals, Inc.
574,835$3.2B0.03%
65
Menlo Therapeutics Inc.
700,000$2.9B0.02%
66
Aevi Genomic Medicine, Inc.
3,950,419$2.8B0.02%
67
Sierra Oncology, Inc.
2,000,000$2.6B0.02%
68
APLSApellis Pharmaceuticals, Inc.
196,078$2.6B0.02%
69
GTHXEURG1 Therapeutics, Inc.
127,236$2.4B0.02%
70
GLPGGalapagos NV
25,072$2.3B0.02%
71
CCXIEURChemoCentryx, Inc.
207,029$2.3B0.02%
72
YMABUSDY-mAbs Therapeutics, Inc.
102,800$2.1B0.02%
73
ALKSAlkermes plc
67,000$2.0B0.02%
74
ORTXUSDOrchard Therapeutics plc
125,000$2.0B0.02%
75
Foamix Pharmaceuticals Ltd.
498,189$1.8B0.01%
76
NTLAIntellia Therapeutics, Inc.
128,538$1.8B0.01%
77
Achillion Pharmaceuticals, Inc.
1,095,359$1.7B0.01%
78
Adamas Pharmaceuticals, Inc.
172,630$1.5B0.01%
79
GLMDGalmed Pharmaceuticals Ltd.
215,594$1.5B0.01%
80
La Jolla Pharmaceutical Company
154,675$1.5B0.01%
81
VSAREURAravive, Inc.
404,384$1.4B0.01%
82
RCUSArcus Biosciences, Inc.
121,534$1.3B0.01%
83
Molecular Templates, Inc.
254,230$1.0B0.01%
84
TREURTrillium Therapeutics Inc.
505,262$864.0M0.01%
85
DVAXDynavax Technologies Corporation
75,000$686.0M0.01%
86
INFIQInfinity Pharmaceuticals, Inc.
580,400$685.0M0.01%
87
Proteon Therapeutics, Inc.
298,591$678.0M0.01%
88
AQSTAquestive Therapeutics, Inc.
99,600$627.0M0.01%
89
Affimed N.V.
200,000$622.0M0.01%
90
Constellation Pharmaceuticals, Inc.
133,333$535.0M0.00%
91
FLGTFulgent Genetics, Inc.
125,000$396.0M0.00%
92
Sunesis Pharmaceuticals, Inc.
556,665$231.0M0.00%
93
Ritter Pharmaceuticals, Inc.
279,999$168.0M0.00%