Sofinnova Investments, Inc. Q3 2025 Filing

Filed November 14, 2025

Portfolio Value

$1.8T

Holdings

59

Report Date

Q3 2025

Filing Type

13F-HR

All Holdings (59 positions)

#StockSharesValue% PortfolioType
1
NTRANatera Inc
1,550,280$249.5B13.65%
2
GILDGilead Sciences Inc
1,252,312$139.0B7.60%
3
UTHUnited Therapeutics Corp
287,726$120.6B6.60%Put
4
VERAVera Therapeutics Inc
2,793,987$81.2B4.44%
5
JAZZJazz Pharmaceuticals PLC
588,828$77.6B4.24%
6
AZNAstraZeneca PLC
823,933$63.2B3.46%
7
RAPPRapport Therapeutics Inc
1,947,579$57.8B3.16%
8
BSXBoston Scientific Corp
569,427$55.6B3.04%
9
QUREUniqure NV
936,862$54.7B2.99%Put
10
DC4Dexcom Inc
779,616$52.5B2.87%
11
ISRGIntuitive Surgical Inc
110,896$49.6B2.71%
12
AXSMAxsome Therapeutics Inc
393,499$47.8B2.61%
13
ROIVRoivant Sciences Ltd
3,149,270$47.6B2.61%
14
IBBiShares TR
325,000$46.9B2.57%Put
15
VRTXVertex Pharmaceuticals Inc
117,875$46.2B2.52%
16
BBIOBridgeBio Pharma Inc
831,847$43.2B2.36%
17
XBISPDR Series Trust
400,000$40.1B2.19%Put
18
RNAAvidity Biosciences Inc
875,925$38.2B2.09%
19
ABBVAbbVie Inc
150,966$35.0B1.91%
20
AVBPArrivent BioPharma Inc
1,696,752$31.3B1.71%
21
COGTCogent Biosciences Inc
2,127,941$30.6B1.67%
22
GKOSGlaukos Corp
312,994$25.5B1.40%
23
IDYAIDEAYA Biosciences Inc
922,695$25.1B1.37%
24
RYTMRhythm Pharmaceuticals Inc
246,966$24.9B1.36%
25
AKROAkero Therapeutics Inc
473,625$22.5B1.23%
26
APGEApogee Therapeutics Inc
565,417$22.5B1.23%
27
EXASExact Sciences Corp
365,000$20.0B1.09%
28
IMTXImmatics N.V
2,227,837$19.0B1.04%
29
SMMTSummit Therapeutics Inc
900,000$18.6B1.02%Call
30
PHVSPharvaris N V
739,876$18.5B1.01%
31
SUPNSupernus Pharmaceuticals Inc
377,066$18.0B0.99%
32
RCUSArcus Biosciences Inc
1,222,263$16.6B0.91%
33
MRUSMerus N V
166,729$15.7B0.86%
34
IM8NInsmed Inc
104,339$15.0B0.82%
35
INBXInhibrx Biosciences Inc
440,092$14.8B0.81%
36
BIOABioAge Labs Inc
2,293,788$13.5B0.74%
37
CELCCelcuity Inc
253,375$12.5B0.68%
38
DYNDyne Therapeutics Inc
985,828$12.5B0.68%
39
PTCTPTC Therapeutics Inc
186,932$11.5B0.63%
40
GEHCGE Healthcare Technologies Inc
151,085$11.3B0.62%
41
SLNOSoleno Therapeutics Inc
166,281$11.2B0.61%
42
PRAXPraxis Precision Medicines Inc
172,833$9.2B0.50%
43
YB4PSavara Inc
2,427,724$8.7B0.47%
44
EWTXEdgewise Therapeutics Inc
520,240$8.4B0.46%
45
ANABAnaptysBio Inc
254,268$7.8B0.43%
46
CMPXCompass Therapeutics Inc
2,028,886$7.1B0.39%
47
NKTRNektar Therapeutics
118,419$6.7B0.37%
48
LQDALiquidia Corporation
250,000$5.7B0.31%Put
49
CDTXCidara Therapeutics Inc
54,197$5.2B0.28%
50
IMNMImmunome Inc
436,051$5.1B0.28%
51
NXTCNextcure Inc
222,654$1.3B0.07%
52
WVEWave Life Sciences Ltd
170,943$1.3B0.07%
53
SRRKScholar Rock Hldg Corp
31,410$1.2B0.06%
54
JBIOJade Biosciences Inc
107,391$926.8M0.05%
55
IRONDisc Medicine Inc
13,553$895.6M0.05%
56
BOLTBolt Biotherapeutics Inc
137,721$732.7M0.04%
57
ACADAcadia Pharmaceuticals Inc
26,800$571.9M0.03%
58
ESTAEstablishment Labs Hldgs Inc
10,787$442.2M0.02%
59
IMAImageneBio Inc
31,884$259.9M0.01%