Sofinnova Investments, Inc.

CIK: 0001631134Latest portfolio: $2.3B · Q4 2025

Holdings

60

Total Value

$2.3B

New Positions

11

Closed Positions

10

#StockSharesValue% PortfolioChangeType
1
NTRANATERA INC
1,550,280$355.2M15.31%
2
JAZZJAZZ PHARMACEUTICALS PLC
959,860$163.2M7.04%+371K
3
AZNASTRAZENECA PLC
1,632,334$150.1M6.47%+808K
4
VERAVERA THERAPEUTICS INC
2,793,987$141.5M6.10%
5
BMYBRISTOL-MYERS SQUIBB CO
1,512,994$81.6M3.52%NEW
6
UTHUNITED THERAPEUTICS CORP
157,641$76.8M3.31%NEW
7
VRTXVERTEX PHARMACEUTICALS INC
164,594$74.6M3.22%+47K
8
ABBVABBVIE INC
317,783$72.6M3.13%+167K
9
ISRGINTUITIVE SURGICAL INC
126,968$71.9M3.10%+16K
10
COGTCOGENT BIOSCIENCES INC
1,973,625$70.1M3.02%-154,316
11
LLYELI LILLY & CO
61,652$66.3M2.86%NEW
12
RAPPRAPPORT THERAPEUTICS INC
1,904,408$57.8M2.49%-43,171
13
BBIOBRIDGEBIO PHARMA INC
720,448$55.1M2.38%-111,399
14
RNAAVIDITY BIOSCIENCES INC
745,116$53.7M2.32%-130,809
15
DYNDYNE THERAPEUTICS INC
2,254,161$44.1M1.90%+1.3M
16
BMRNBIOMARIN PHARMACEUTICAL INC
697,133$41.4M1.79%NEW
17
APGEAPOGEE THERAPEUTICS INC
534,845$40.4M1.74%-30,572
18
CDTXCIDARA THERAPEUTICS INC
180,265$39.8M1.72%+126K
19
PRAXPRAXIS PRECISION MEDICINES INC
125,722$37.1M1.60%-47,111
20
IMTXIMMATICS N.V
3,435,542$36.1M1.56%+1.2M
21
INBXINHIBRX BIOSCIENCES INC
454,657$35.9M1.55%+15K
22
IMNMIMMUNOME INC
1,618,477$34.8M1.50%+1.2M
23
AVBPARRIVENT BIOPHARMA INC
1,696,752$34.1M1.47%
24
GKOSGLAUKOS CORP
288,128$32.5M1.40%-24,866
25
IDYAIDEAYA BIOSCIENCES INC
885,121$30.6M1.32%-37,574

Quarterly Changes

New Positions

Closed Positions

Increased Positions

NameSharesChange
CMPX3.4M+1.3M
IMTX3.4M+1.2M
JAZZ960K+371K
NKTR439K+320K
SUPN553K+176K
ABBV318K+167K
IM8N157K+52K
VRTX165K+47K
CELC299K+46K
ACAD66K+39K

Decreased Positions

NameSharesChange
DC4378K-401397
AXSM12K-381233
EXAS101K-263557
COGT2.0M-154316
SLNO12K-153867
RNA745K-130809
RCUS1.1M-125558
BBIO720K-111399
EWTX438K-82421
PRAX126K-47111

Sector Breakdown

Healthcare0.0% ($3.5515316317615004e+245T)
Unknown0.0% ($7681039818272891904.0T)

Filing History

QuarterFiling DatePortfolio ValueHoldings
Q4 2025Feb 13, 2026$2.3B60
Q3 2025Nov 14, 2025$1.8T62
Q2 2025Aug 14, 2025$1.6T63
Q1 2025May 15, 2025$1.5T65
Q4 2024Feb 14, 2025$1.4T61
Q3 2024Nov 13, 2024$1260.0T62
Q2 2024Aug 9, 2024$1924.2T82
Q1 2024May 15, 2024$1795.1T74
Q4 2023Feb 13, 2024$1787.1T64
Q3 2023Nov 14, 2023$1585.2T69
Q2 2023Aug 14, 2023$1526.8T55
Q1 2023May 11, 2023$1563.6T53
Q4 2022Feb 14, 2023$1685.2T53
Q3 2022Nov 8, 2022$1.7T61
Q2 2022Aug 15, 2022$1.2T61
Q1 2022May 16, 2022$1.3T64
Q4 2021Feb 14, 2022$1.7T72
Q3 2021Nov 15, 2021$1.7T70
Q2 2021Aug 16, 2021$1.7T67
Q1 2021May 14, 2021$1.7T64
Q4 2020Feb 16, 2021$1.7T69
Q3 2020Nov 13, 2020$1.3T157
Q2 2020Aug 13, 2020$1.6T186
Q1 2020May 13, 2020$1.1T150
Q4 2019Feb 14, 2020$1.4T135
Q3 2019Nov 14, 2019$1.1T167
Q2 2019Aug 13, 2019$1.1T163
Q1 2019May 15, 2019$1.0T164
Q4 2018Feb 14, 2019$767.9B136
Q3 2018Nov 15, 2018$1.1T144
Q2 2018Aug 14, 2018$685.3B59
Q1 2018May 15, 2018$581.8B55

Fund Information

CIK0001631134
Most Recent FilingFeb 13, 2026
Number of Filings32

Sofinnova Investments, Inc. is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $2.3B across 60 holdings. The largest position is NATERA INC (NTRA), representing 15.3% of the portfolio. Compared to the previous quarter, the fund opened 13 new positions and closed 12 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.