Sofinnova Investments, Inc. Q2 2025 Filing

Filed August 14, 2025

Portfolio Value

$1.6T

Holdings

58

Report Date

Q2 2025

Filing Type

13F-HR

All Holdings (58 positions)

#StockSharesValue% PortfolioType
1
NTRANatera Inc
1,550,280$261.9B16.02%
2
GILDGilead Sciences Inc
1,050,308$116.4B7.12%
3
LLYEli Lilly and Co
97,018$75.6B4.63%
4
JAZZJazz Pharmaceuticals PLC
694,096$73.7B4.50%
5
VERAVera Therapeutics Inc
2,793,987$65.8B4.03%
6
IWMiShares TR
250,000$53.9B3.30%Put
7
RYTMRhythm Pharmaceuticals Inc
811,010$51.2B3.13%Put
8
ABBVAbbVie Inc
265,850$49.3B3.02%
9
IBBiShares TR
375,000$47.4B2.90%Put
10
BSXBoston Scientific Corp
431,200$46.3B2.83%
11
ROIVRoivant Sciences Ltd
4,088,814$46.1B2.82%Call
12
DC4Dexcom Inc
523,694$45.7B2.80%
13
IDYAIDEAYA Biosciences Inc
2,147,795$45.1B2.76%
14
BBIOBridgeBio Pharma Inc
993,093$42.9B2.62%
15
ISRGIntuitive Surgical Inc
70,642$38.4B2.35%
16
AVBPArrivent BioPharma Inc
1,696,752$36.9B2.26%
17
SLNOSoleno Therapeutics Inc
415,219$34.8B2.13%
18
UTHUnited Therapeutics Corp
118,513$34.1B2.08%
19
IM8NInsmed Inc
313,923$31.6B1.93%
20
REPLReplimune Group Inc
3,306,529$30.7B1.88%Put
21
AKROAkero Therapeutics Inc
548,788$29.3B1.79%
22
SUPNSupernus Pharmaceuticals Inc
799,253$25.2B1.54%
23
ANABAnaptysBio Inc
1,032,362$22.9B1.40%
24
RAPPRapport Therapeutics Inc
1,995,594$22.7B1.39%
25
QUREUniqure NV
1,558,356$21.7B1.33%
26
COGTCogent Biosciences Inc
3,015,505$21.7B1.32%Call
27
MRUSMerus N V
404,562$21.3B1.30%
28
AZNAstraZeneca PLC
293,661$20.5B1.26%
29
PTCTPTC Therapeutics Inc
375,939$18.4B1.12%
30
INZYInozyme Pharma Inc
4,280,308$17.1B1.05%
31
CDTXCidara Therapeutics Inc
351,031$17.1B1.05%Call
32
RNAAvidity Biosciences Inc
584,801$16.6B1.02%
33
SMMTSummit Therapeutics Inc
700,000$14.9B0.91%Call
34
SNDXSyndax Pharmaceuticals Inc
1,524,440$14.3B0.87%
35
IMTXImmatics N.V
2,240,528$12.1B0.74%
36
EXASExact Sciences Corp
208,300$11.1B0.68%
37
PHVSPharvaris N V
585,532$10.3B0.63%
38
INBXInhibrx Biosciences Inc
708,678$10.1B0.62%
39
RCUSArcus Biosciences Inc
1,216,016$9.9B0.61%
40
YMABUSDY-mAbs Therapeutics Inc
2,194,278$9.9B0.61%
41
AXSMAxsome Therapeutics Inc
93,610$9.8B0.60%
42
BIOABioAge Labs Inc
2,304,901$9.5B0.58%
43
EWTXEdgewise Therapeutics Inc
716,873$9.4B0.57%
44
IMNMImmunome Inc
778,476$7.2B0.44%
45
DYNDyne Therapeutics Inc
614,865$5.9B0.36%
46
YB4PSavara Inc
2,457,352$5.6B0.34%
47
APGEApogee Therapeutics Inc
76,180$3.3B0.20%
48
NXTCNextcure Inc
2,671,856$1.2B0.08%
49
ESTAEstablishment Labs Hldgs Inc
28,120$1.2B0.07%
50
JBIOJade Biosciences Inc
107,391$1.1B0.07%
51
MTSRMetsera Inc
36,191$1.0B0.06%
52
SRRKScholar Rock Hldg Corp
26,440$936.5M0.06%
53
BOLTBolt Biotherapeutics Inc
137,721$794.6M0.05%
54
WVEWave Life Sciences Ltd
117,903$766.4M0.05%
55
GPCRStructure Therapeutics Inc
34,353$712.5M0.04%
56
PRAXPraxis Precision Medicines Inc
15,717$660.9M0.04%
57
Ikena Oncology Inc
382,616$512.7M0.03%
58
IRONDisc Medicine Inc
7,312$387.2M0.02%