Sio Capital Management, LLC Q4 2025 Filing

Filed February 17, 2026

Portfolio Value

$635.7M

Holdings

68

Report Date

Q4 2025

Filing Type

13F-HR

All Holdings (68 positions)

#StockSharesValue% PortfolioType
1
CELCCELCUITY INC
477,067$47.6M7.48%
2
CITHE CIGNA GROUP
172,203$47.4M7.46%
3
SNYSANOFI SA
971,686$47.1M7.41%
4
MMSMAXIMUS INC
500,304$43.2M6.79%
5
ZBHZIMMER BIOMET HOLDINGS INC
385,642$34.7M5.45%
6
RYTMRHYTHM PHARMACEUTICALS INC
265,700$28.4M4.47%Put
7
KVUEKENVUE INC
1,465,442$25.3M3.98%
8
OGNORGANON & CO
3,421,765$24.5M3.86%
9
ICLRICON PLC
127,202$23.2M3.65%
10
WAYWAYSTAR HLDG CORP
613,725$20.1M3.16%
11
LIVNLIVANOVA PLC
322,382$19.8M3.12%
12
DNTHDIANTHUS THERAPEUTICS INC
474,503$19.6M3.08%
13
BHVNBIOHAVEN LTD
1,244,764$14.1M2.21%
14
GPCRSTRUCTURE THERAPEUTICS INC
201,500$14.0M2.20%
15
TYRATYRA BIOSCIENCES INC
526,002$13.8M2.18%
16
BMRNBIOMARIN PHARMACEUTICAL INC
232,688$13.8M2.18%
17
BTSGBRIGHTSPRING HEALTH SVCS INC
308,010$11.5M1.81%
18
CNCCENTENE CORP DEL
274,350$11.3M1.78%
19
CRLCHARLES RIV LABS INTL INC
54,985$11.0M1.73%
20
TFXTELEFLEX INCORPORATED
86,876$10.6M1.67%
21
AVRANTERIS TECHNOLOGIES GLOBAL
1,874,641$9.4M1.47%
22
TARAPROTARA THERAPEUTICS INC
1,715,394$9.1M1.44%
23
XXYCROSS CTRY HEALTHCARE INC
1,068,821$8.7M1.36%
24
HAEHAEMONETICS CORP MASS
92,631$7.4M1.17%
25
BSFAANI PHARMACEUTICALS INC
87,272$6.9M1.08%
26
AQSTAQUESTIVE THERAPEUTICS INC
993,095$6.4M1.01%
27
DRUGBRIGHT MINDS BIOSCIENCES INC
81,883$6.4M1.01%
28
EWTXEDGEWISE THERAPEUTICS INC
237,481$5.9M0.93%
29
ABVXABIVAX SA
43,124$5.8M0.91%
30
CRNXCRINETICS PHARMACEUTICALS IN
124,841$5.8M0.91%
31
RAPPRAPPORT THERAPEUTICS INC
185,265$5.6M0.88%
32
ABGCENCORA INC
15,900$5.4M0.84%
33
MCKMCKESSON CORP
6,400$5.2M0.83%
34
IRONDISC MEDICINE INC
57,586$4.6M0.72%
35
PRQRPROQR THERAPEUTICS N V
2,164,181$4.4M0.69%
36
FULCFULCRUM THERAPEUTICS INC
382,000$4.3M0.68%
37
YB4PSAVARA INC
613,888$3.7M0.58%
38
ORKAORUKA THERAPEUTICS INC
118,126$3.6M0.56%
39
VTYXVENTYX BIOSCIENCES INC
387,751$3.5M0.55%
40
PMVPPMV PHARMACEUTICALS INC
2,636,548$3.3M0.52%
41
SISHOULDER INNOVATIONS INC
227,971$3.3M0.51%
42
ALGSALIGOS THERAPEUTICS INC
335,937$3.1M0.49%
43
VIRVIR BIOTECHNOLOGY INC
478,343$2.9M0.45%
44
ALKSALKERMES PLC
95,353$2.7M0.42%
45
IDYAIDEAYA BIOSCIENCES INC
75,730$2.6M0.41%
46
KYMRKYMERA THERAPEUTICS INC
32,235$2.5M0.39%
47
ELTXELICIO THERAPEUTICS INC
296,900$2.4M0.37%Put
48
OVIDOVID THERAPEUTICS INC
1,427,495$2.3M0.37%
49
CNTXCONTEXT THERAPEUTICS INC
1,341,636$2.0M0.31%
50
HYPRHYPERFINE INC
2,000,000$2.0M0.31%
51
OTLKOUTLOOK THERAPEUTICS INC
1,125,400$1.8M0.28%Put
52
BBOTBRIDGEBIO ONCOLOGY THERAPEUT
130,628$1.6M0.26%
53
IBIOIBIO INC
740,000$1.4M0.22%
54
XLOXILIO THERAPEUTICS INC
2,134,537$1.4M0.21%
55
ADGMADAGIO MED HLDGS INC
1,288,461$1.3M0.21%
56
AVTXAVALO THERAPEUTICS INC
72,173$1.3M0.21%
57
NMTCNEUROONE MED TECHNOLOGIES CO
1,140,040$864K0.14%
58
TELATELA BIO INC
636,300$750K0.12%
59
FHTXFOGHORN THERAPEUTICS INC
122,889$663K0.10%
60
SENSSENSEONICS HLDGS INC
115,784$639K0.10%
61
ENTAENANTA PHARMACEUTICALS INC
40,000$630K0.10%
62
TERNTERNS PHARMACEUTICALS INC
10,100$408K0.06%
63
MODDMODULAR MED INC
785,824$286K0.04%
64
NYXHNYXOAH S A
50,839$233K0.04%
65
BOLDBOUNDLESS BIO INC
163,679$196K0.03%
66
NXTCNEXTCURE INC
10,940$155K0.02%
67
RCKTWROCKET PHARMACEUTICALS INC
400,000$7K0.00%
68
HUMAWHUMACYTE INC
49,998$4K0.00%