Opaleye Management Inc. Q2 2025 Filing

Filed August 14, 2025

Portfolio Value

$498.9B

Holdings

41

Report Date

Q2 2025

Filing Type

13F-HR

All Holdings (41 positions)

#StockSharesValue% PortfolioType
1
HROWHARROW HEALTH INC
3,905,000$119.3B23.90%
2
ETONETON PHARMACEUTICALS INC
2,860,000$40.8B8.17%
3
IMNMIMMUNOME INC
3,529,581$32.8B6.58%
4
SNWVSANUWAVE HEALTH INC
980,000$32.2B6.45%
5
LQDALIQUIDIA CORPORATION
2,475,000$30.8B6.18%
6
CDXSCODEXIS INC
12,600,000$30.7B6.16%
7
RYTMRHYTHM PHARMACEUTICALS INC
475,000$30.0B6.02%
8
TGTXTG THERAPEUTICS INC
535,000$19.3B3.86%
9
OCULOCULAR THERAPEUTIX INC
1,595,000$14.8B2.97%
10
ARVNARVINAS INC
1,680,000$12.4B2.48%
11
LRMRLARIMAR THERAPEUTICS INC
4,110,000$11.9B2.38%
12
IRONDISC MEDICINE INC
186,418$9.9B1.98%
13
SRPTSAREPTA THERAPEUTICS INC
500,000$8.6B1.71%
14
VIGLVIGIL NEUROSCIENCES INC
1,000,000$8.0B1.59%
15
TARAPROTARA THERAPEUTICS INC
855,000$7.4B1.48%
16
CGONCG ONCOLOGY INC
266,000$6.9B1.39%
17
XOMAXOMA CORP DEL
255,087$6.4B1.29%
18
EWTXEDGEWISE THERAPEUTICS INC
490,000$6.4B1.29%
19
STOKSTOKE THERAPEUTICS INC
562,120$6.4B1.28%
20
ANIKANIKA THERAPEUTICS INC
588,797$6.2B1.25%
21
GOSS 5 06/01/27GOSSAMER BIO INC
11,500,000$5.9B1.19%
22
PTGXPROTAGONIST THERAPEUTICS INC
105,000$5.8B1.16%
23
DNAGINKGO BIOWORKS HOLDINGS
500,000$5.6B1.13%
24
KPTI 3 10/15/25KARYOPHARM THERAPEUTICS INC
6,000,000$4.6B0.91%
25
GOSSGOSSAMER BIO INC
3,545,000$4.4B0.87%
26
RZLTREZOLUTE INC
903,442$4.0B0.81%
27
RVMDREVOLUTION MEDICINES INC
105,000$3.9B0.77%
28
EPIEURESSA PHARMA INC
2,209,998$3.8B0.75%
29
CRGXCARGO THERAPEUTICS INC
666,503$2.7B0.55%
30
MBXMBX BIOSCIENCES INC
239,319$2.7B0.55%
31
ZYMEZYMEWORKS INC
210,000$2.6B0.53%
32
ALMSALUMIS INC
775,000$2.3B0.47%
33
ZNTLZENTALIS PHARMACEUTICALS INC
1,924,300$2.2B0.45%
34
TRVITREVI THERAPEUTICS INC
390,000$2.1B0.43%
35
RCELAVITA MEDICAL INC
389,519$2.1B0.41%
36
IRDOPUS GENETICS INC
1,220,000$1.1B0.23%
37
DERMJOURNEY MEDICAL CORP
95,000$682.1M0.14%
38
ELEVATION ONCOLOGY INC
1,442,061$529.4M0.11%
39
IBIOIBIO INC
375,000$285.0M0.06%
40
PEPGPEPGEN INC
240,000$266.4M0.05%
41
ADGMADAGIO MED HLDGS INC
110,571$143.7M0.03%