BAKER BROS. ADVISORS LP Q1 2019 Filing

Filed May 15, 2019

Portfolio Value

$15.6T

Holdings

96

Report Date

Q1 2019

Filing Type

13F-HR

All Holdings (96 positions)

#StockSharesValue% PortfolioType
1
SGENEURSeattle Genetics, Inc.
51,049,760$3.7T23.93%
2
INCYIncyte Corporation
34,271,827$2.9T18.87%
3
ONCBeiGene, Ltd.
11,959,824$1.6T10.11%
4
ALXNAlexion Pharmaceuticals, Inc.
8,558,068$1.2T7.41%
5
ACADACADIA Pharmaceuticals Inc.
39,713,842$1.1T6.83%
6
AMRNAmarin Corporation plc
43,210,459$897.0B5.74%
7
Genomic Health, Inc.
10,198,943$714.4B4.57%
8
BMRNBioMarin Pharmaceutical Inc.
7,589,294$674.2B4.32%
9
ASNDAscendis Pharma A/S
3,390,270$399.0B2.55%
10
MRTXEURMirati Therapeutics, Inc.
2,513,462$184.2B1.18%
11
MDGLMadrigal Pharmaceuticals, Inc.
1,169,278$146.5B0.94%
12
ARGXargenx SE
1,019,557$127.3B0.81%
13
BCRXBioCryst Pharmaceuticals, Inc.
15,118,081$123.1B0.79%
14
HRTXHeron Therapeutics, Inc.
5,018,104$122.6B0.79%
15
Clementia Pharmaceuticals Inc.
3,724,445$97.2B0.62%
16
NBIXNeurocrine Biosciences, Inc.
1,098,670$96.8B0.62%
17
ARRYEURArray BioPharma Inc.
3,842,289$93.7B0.60%
18
NVTA1EURInvitae Corporation
3,902,421$91.4B0.59%
19
Spark Therapeutics, Inc.
751,927$85.6B0.55%
20
CBAYUSDCymaBay Therapeutics, Inc.
5,707,411$75.8B0.49%
21
RYTMRhythm Pharmaceuticals, Inc.
2,708,200$74.2B0.48%
22
GW Pharmaceuticals plc
428,345$72.2B0.46%
23
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
53,270,000$72.0B0.46%
24
1T7Tricida, Inc.
1,803,238$69.6B0.45%
25
CERSCerus Corporation
10,749,937$67.0B0.43%
26
Audentes Therapeutics, Inc.
1,715,183$66.9B0.43%
27
Principia Biopharma Inc.
1,787,807$60.8B0.39%
28
IM8NInsmed Incorporated
2,077,601$60.4B0.39%
29
KODKodiak Sciences Inc.
9,145,115$59.7B0.38%
30
KNSAKiniksa Pharmaceuticals, Ltd.
3,000,000$54.2B0.35%
31
MyoKardia, Inc.
1,016,306$52.8B0.34%
32
DBV Technologies S.A.
5,509,560$42.5B0.27%
33
QUREuniQure N.V.
605,000$36.1B0.23%
34
Aquinox Pharmaceuticals, Inc.
10,934,154$29.5B0.19%
35
Zymeworks Inc.
1,708,472$27.6B0.18%
36
KRYSKrystal Biotech, Inc.
784,674$25.8B0.17%
37
Ra Pharmaceuticals, Inc.
823,113$18.4B0.12%
38
MRUSMerus N.V.
1,160,014$17.1B0.11%
39
AXSMAxsome Therapeutics, Inc.
1,200,000$17.1B0.11%
40
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$15.4B0.10%
41
Aimmune Therapeutics, Inc.
673,908$15.1B0.10%
42
CPRXCatalyst Pharmaceuticals, Inc.
2,900,000$14.8B0.09%
43
AGLEUSDAeglea BioTherapeutics, Inc.
1,713,604$13.8B0.09%
44
XNCRXencor, Inc.
428,120$13.3B0.09%
45
Idera Pharmaceuticals, Inc.
4,839,895$12.3B0.08%
46
Dermira, Inc.
906,943$12.3B0.08%
47
TPIVDEURMarker Therapeutics, Inc.
1,500,000$9.9B0.06%
48
GBYSangamo Therapeutics, Inc.
999,823$9.5B0.06%
49
Abeona Therapeutics Inc.
1,288,235$9.5B0.06%
50
Bellicum Pharmaceuticals, Inc.
2,677,818$9.0B0.06%
51
ANABAnaptysBio, Inc.
113,086$8.3B0.05%
52
BDQMAlbireo Pharma, Inc.
250,000$8.1B0.05%
53
IFRXInflaRx N.V.
178,987$6.8B0.04%
54
Spring Bank Pharmaceuticals, Inc.
613,144$6.4B0.04%
55
bluebird bio, Inc.
40,000$6.3B0.04%
56
APLSApellis Pharmaceuticals, Inc.
313,725$6.1B0.04%
57
Menlo Therapeutics Inc.
700,000$5.5B0.04%
58
MGNXMacroGenics, Inc.
302,600$5.4B0.03%
59
Syros Pharmaceuticals, Inc.
574,835$5.3B0.03%
60
PTGXProtagonist Therapeutics, Inc.
403,893$5.1B0.03%
61
AUTLAutolus Therapeutics plc
156,773$4.9B0.03%
62
HALOHalozyme Therapeutics, Inc.
299,969$4.8B0.03%
63
VKTXViking Therapeutics, Inc.
425,000$4.2B0.03%
64
Forty Seven, Inc.
250,000$4.0B0.03%
65
XLRNAcceleron Pharma Inc.
83,900$3.9B0.03%
66
Acorda Therapeutics, Inc.
292,134$3.9B0.02%
67
Sierra Oncology, Inc.
2,000,000$3.4B0.02%
68
La Jolla Pharmaceutical Company
505,240$3.2B0.02%
69
Achillion Pharmaceuticals, Inc.
1,095,359$3.2B0.02%
70
VSAREURAravive, Inc.
430,885$3.0B0.02%
71
CRNXCrinetics Pharmaceuticals, Inc.
131,250$3.0B0.02%
72
GLPGGalapagos NV
25,072$3.0B0.02%
73
ASMBAssembly Biosciences, Inc.
148,587$2.9B0.02%
74
CCXIEURChemoCentryx, Inc.
207,029$2.9B0.02%
75
YMABUSDY-mAbs Therapeutics, Inc.
102,800$2.7B0.02%
76
ALKSAlkermes plc
67,000$2.4B0.02%
77
ORTXUSDOrchard Therapeutics plc
125,000$2.2B0.01%
78
NTLAIntellia Therapeutics, Inc.
128,538$2.2B0.01%
79
GTHXEURG1 Therapeutics, Inc.
127,236$2.1B0.01%
80
CTMXCytomX Therapeutics, Inc.
194,377$2.1B0.01%
81
Harpoon Therapeutics, Inc.
214,285$2.0B0.01%
82
Foamix Pharmaceuticals Ltd.
498,189$1.9B0.01%
83
Constellation Pharmaceuticals, Inc.
133,333$1.8B0.01%
84
GLMDGalmed Pharmaceuticals Ltd.
215,594$1.8B0.01%
85
RCUSArcus Biosciences, Inc.
121,534$1.5B0.01%
86
Molecular Templates, Inc.
254,230$1.5B0.01%
87
Adamas Pharmaceuticals, Inc.
172,630$1.2B0.01%
88
ContraFect Corporation
2,914,536$1.2B0.01%
89
INFIQInfinity Pharmaceuticals, Inc.
580,400$1.1B0.01%
90
Affimed N.V.
200,000$840.0M0.01%
91
FLGTFulgent Genetics, Inc.
125,000$744.0M0.00%
92
AQSTAquestive Therapeutics, Inc.
99,600$688.0M0.00%
93
Sunesis Pharmaceuticals, Inc.
556,665$676.0M0.00%
94
DVAXDynavax Technologies Corporation
75,000$548.0M0.00%
95
TREURTrillium Therapeutics Inc.
505,262$333.0M0.00%
96
Ritter Pharmaceuticals, Inc.
279,999$244.0M0.00%