5AM Venture Management, LLC

CIK: 0001799883SEC EDGAR →

Portfolio Value

$318.1B

Holdings

21

As of

Q4 2025

New Positions

1

Closed Positions

4

Portfolio Value History

Top 10 Holdings

RankStockSharesValue% of Portfolio
1

ENTRADA THERAPEUTICS INC

4,056,379$41.7B
13.11%
2

CAMP4 THERAPEUTICS CORP

5,869,091$36.0B
11.31%
3

TYRA BIOSCIENCES INC

1,029,298$27.1B
8.51%
4

VIRIDIAN THERAPEUTICS INC

736,595$22.9B
7.21%
5

PHARVARIS N V

797,600$22.1B
6.96%
6

ERASCA INC

5,405,404$20.1B
6.32%
7

EYEPOINT INC

1,050,000$19.2B
6.03%
8

MAPLIGHT THERAPEUTICS INC

950,011$16.7B
5.25%
9

CENTESSA PHARMACEUTICALS PLC

580,945$14.5B
4.57%
10

CELLDEX THERAPEUTICS INC NEW

497,270$13.5B
4.25%

Quarterly Changes

Top Buys

MPLTNEW
$16.7B
TYRA↑ Increased
$13.9B
SRZN↑ Increased
$4.8B
TECX↑ Increased
$4.6B
ZNTL↑ Increased
$4.6B

Top Sells

TRDA↓ Decreased
$17.0B
DNTHCLOSED
$14.4B
PRAXCLOSED
$9.0B
ALECCLOSED
$2.9B
AVU0CLOSED
$2.5B

New Positions (1)

$16.7B · 950K shares

Closed Positions (5)

$14.4B · 365K shares
$9.0B · 170K shares
$2.9B · 996K shares
$2.5B · 542K shares
$405.1M · 52K shares

Sector Breakdown

Sector# HoldingsValue%
Healthcare20$304.6B95.8%
Unknown1$13.5B4.2%