| 1 | Column Group LLC | 1,851,350 | $41.8M | 50.54% | Share |
| 2 | MILLENNIUM MANAGEMENT LLC | 721,266 | $16.0M | 0.01% | Share |
| 3 | VR Adviser, LLC | 632,931 | $14.3M | 0.71% | Share |
| 4 | BRAIDWELL LP | 470,000 | $10.6M | 0.34% | Share |
| 5 | Spruce Street Capital LP | 432,040 | $9.8M | 3.23% | Share |
| 6 | Boxer Capital Management, LLC | 416,150 | $9.4M | 2.06% | Share |
| 7 | 5AM Venture Management, LLC | 387,500 | $8.8M | 2.75% | Share |
| 8 | STEMPOINT CAPITAL LP | 290,108 | $6.6M | 1.12% | Share |
| 9 | VANGUARD GROUP INC | 281,276 | $6.4M | 0.00% | Share |
| 10 | STEMPOINT CAPITAL LP | 329,658 | $6.1M | 1.05% | Share |
| 11 | Vivo Capital, LLC | 260,000 | $5.9M | 0.38% | Share |
| 12 | Nantahala Capital Management, LLC | 229,527 | $5.2M | 0.17% | Share |
| 13 | Woodline Partners LP | 230,572 | $5.0M | 0.02% | Share |
| 14 | ACUTA CAPITAL PARTNERS, LLC | 178,415 | $4.0M | 2.74% | Share |
| 15 | BALYASNY ASSET MANAGEMENT L.P. | 190,489 | $4.0M | 0.01% | Share |
| 16 | SILVERARC CAPITAL MANAGEMENT, LLC | 157,323 | $3.6M | 0.49% | Share |
| 17 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207 | $3.0M | 0.14% | Share |
| 18 | Stonepine Capital Management, LLC | 113,631 | $2.6M | 1.87% | Share |
| 19 | Empery Asset Management, LP | 103,974 | $2.3M | 2.07% | Share |
| 20 | Eversept Partners, LP | 95,286 | $2.2M | 0.11% | Share |
| 21 | FRED ALGER MANAGEMENT, LLC | 99,560 | $2.0M | 0.01% | Share |
| 22 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,653 | $2.0M | 0.00% | Share |
| 23 | Euclidean Capital LLC | 87,696 | $2.0M | 0.54% | Share |
| 24 | Kalehua Capital Management LLC | 385,178 | $1.9M | 1.87% | Share |
| 25 | Schonfeld Strategic Advisors LLC | 74,645 | $1.7M | 0.01% | Share |
| 26 | Ikarian Capital, LLC | 65,788 | $1.5M | 0.12% | Share |
| 27 | ArrowMark Colorado Holdings LLC | 55,123 | $1.2M | 0.03% | Share |
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 53,329 | $1.0M | 0.00% | Share |
| 29 | AMERIPRISE FINANCIAL INC | 65,688 | $1.0M | 0.00% | Share |
| 30 | 683 Capital Management, LLC | 41,999 | $949K | 0.04% | Share |
| 31 | VANGUARD GROUP INC | 35,390 | $799K | 0.00% | Share |
| 32 | Persistent Asset Partners Ltd | 4,359 | $98K | 0.04% | Share |
| 33 | VANGUARD GROUP INC | 2,570 | $58K | 0.00% | Share |
| 34 | China Universal Asset Management Co., Ltd. | 1,500 | $33K | 0.00% | Share |
| 35 | UBS Group AG | 54 | $1K | 0.00% | Share |
| 36 | ACADIAN ASSET MANAGEMENT LLC | 1,508 | $0 | 0.00% | Share |
| 37 | MORGAN STANLEY | 547 | $0 | 0.00% | Share |
| 38 | MORGAN STANLEY | 34,911 | $0 | 0.00% | Share |
| 39 | MORGAN STANLEY | 1,503 | $0 | 0.00% | Share |
| 40 | BlackRock, Inc. | 902 | $0 | 0.00% | Share |
| 41 | BlackRock, Inc. | 10,368 | $0 | 0.00% | Share |
| 42 | BlackRock, Inc. | 14,848 | $0 | 0.00% | Share |
| 43 | Alyeska Investment Group, L.P. | 10,188 | $0 | 0.00% | Share |
| 44 | PRICE T ROWE ASSOCIATES INC /MD/ | 21,715 | $0 | 0.00% | Share |
| 45 | NORTHERN TRUST CORP | 13,530 | $0 | 0.00% | Share |
| 46 | BANK OF AMERICA CORP /DE/ | 6 | $0 | 0.00% | Share |
| 47 | BANK OF AMERICA CORP /DE/ | 29,602 | $0 | 0.00% | Share |
| 48 | BOOTHBAY FUND MANAGEMENT, LLC | 18,307 | $0 | 0.00% | Share |
| 49 | Brevan Howard Capital Management LP | 18,921 | $0 | 0.00% | Share |
| 50 | CITADEL ADVISORS LLC | 14,740 | $0 | 0.00% | Share |