Sofinnova Investments, Inc. Q1 2025 Filing

Filed May 15, 2025

Portfolio Value

$1.5T

Holdings

62

Report Date

Q1 2025

Filing Type

13F-HR

All Holdings (62 positions)

#StockSharesValue% PortfolioType
1
NTRANatera Inc
1,550,280$219.2B14.32%
2
SYKStryker Corporation
298,567$111.1B7.26%
3
NDQInvesco QQQ TR
175,000$82.1B5.36%Put
4
SLNOSoleno Therapeutics Inc
1,013,771$72.4B4.73%Put
5
IWMiShares TR
350,000$69.8B4.56%Put
6
VERAVera Therapeutics Inc
2,793,987$67.1B4.38%
7
JAZZJazz Pharmaceuticals PLC
510,050$63.3B4.14%
8
MDTMedtronic PLC
562,992$50.6B3.30%
9
ALNYAlnylam Pharmaceuticals Inc
176,181$47.6B3.11%
10
GILDGilead Sciences Inc
418,900$46.9B3.07%
11
LLYEli Lilly & Co
52,800$43.6B2.85%
12
IDYAIDEAYA Biosciences Inc
2,622,192$43.0B2.81%
13
AVBPArrivent BioPharma Inc
1,696,752$31.4B2.05%
14
PTCTPTC Therapeutics Inc
579,339$29.5B1.93%
15
SNDXSyndax Pharmaceuticals Inc
2,275,223$28.0B1.83%
16
DC4Dexcom Inc
395,975$27.0B1.77%
17
BBIOBridgeBio Pharma Inc
734,227$25.4B1.66%
18
REPLReplimune Group Inc
2,479,939$24.2B1.58%
19
RYTMRhythm Pharmaceuticals
446,839$23.7B1.55%
20
IM8NInsmed Inc
304,254$23.2B1.52%
21
2L9Blueprint Medicines Corp
261,039$23.1B1.51%
22
BMYBristol-Myers Squibb Co
371,497$22.7B1.48%
23
INCYIncyte Corp
357,800$21.7B1.41%
24
ANABAnaptysBio Inc
1,160,033$21.6B1.41%
25
SRPTSarepta Therapeutics Inc
327,618$20.9B1.37%
26
AKROAkero Therapeutics Inc
510,020$20.6B1.35%
27
AXSMAxsome Therapeutics Inc
175,317$20.4B1.34%
28
RAPPRapport Therapeutics Inc
1,995,594$20.0B1.31%
29
SUPNSupernus Pharmaceuticals Inc
520,678$17.1B1.11%
30
YB4PSavara Inc
5,481,666$15.2B0.99%
31
EWTXEdgewise Therapeutics Inc
662,618$14.6B0.95%Put
32
COGTCogent Biosciences Inc
2,182,121$13.1B0.85%
33
ROIVRoivant Sciences Ltd
1,279,510$12.9B0.84%
34
DHRDanaher Corporation
58,606$12.0B0.78%
35
PENPenumbra Inc
42,936$11.5B0.75%
36
RNAAvidity Biosciences Inc
379,931$11.2B0.73%
37
INBXInhibrx Biosciences Inc
697,916$9.8B0.64%
38
YMABUSDY-mAbs Therapeutics Inc
2,194,278$9.7B0.63%
39
AVTEAerovate Therapeutics Inc
3,758,686$9.4B0.62%
40
PHVSPharvaris N V
593,403$9.3B0.61%
41
BIOABioAge Labs Inc
2,304,901$8.7B0.57%
42
ACADACADIA Pharmaceuticals Inc
500,000$8.3B0.54%Call
43
RCUSArcus Biosciences Inc
1,037,776$8.1B0.53%
44
DYNDyne Therapeutics Inc
716,896$7.5B0.49%
45
IMTXImmatics N.V
1,554,304$7.0B0.46%
46
PRAXPraxis Precision Medicines I
157,640$6.0B0.39%
47
ISRGIntuitive Surgical Inc
11,984$5.9B0.39%
48
QUREUniqure NV
545,771$5.8B0.38%
49
IMNMImmunome Inc
788,666$5.3B0.35%
50
KURAKura Oncology Inc
791,667$5.2B0.34%
51
INZYInozyme Pharma Inc
4,280,308$3.9B0.25%
52
SRRKScholar Rock Hldg Corp
116,117$3.7B0.24%
53
ERASErasca Inc
1,877,085$2.6B0.17%
54
NXTCNextcure Inc
2,671,856$1.3B0.08%
55
ESTAEstablishment Labs Hldgs Inc
28,675$1.2B0.08%
56
BOLT1EURBolt Biotherapeutics Inc
2,754,437$1.1B0.07%
57
MTSRMetsera Inc
36,800$1.0B0.07%
58
ELVNEnliven Therapeutics Inc
33,547$660.2M0.04%
59
GPCRStructure Therapeutics Inc
34,952$605.0M0.04%
60
VIRVir Biotechnology Inc
83,010$537.9M0.04%
61
Ikena Oncology Inc
382,616$489.7M0.03%
62
IRONDisc Medicine Inc
7,485$371.6M0.02%