Sofinnova Investments, Inc. Q1 2021 Filing

Filed May 14, 2021

Portfolio Value

$1.7T

Holdings

64

Report Date

Q1 2021

Filing Type

13F-HR

All Holdings (64 positions)

#StockSharesValue% PortfolioType
1
NTRANatera
3,100,560$314.8B18.93%
2
KRTXKaruna Therapeutics, Inc.
1,952,441$234.7B14.11%
3
BOLT1EURBolt Biotherapeutics, Inc.
2,754,437$90.6B5.45%
4
ASNDAscendis Pharma A/S
521,923$67.3B4.04%
5
YMABUSDY-mAbs Therapeutics, Inc
2,194,278$66.4B3.99%
6
AZNAstraZeneca PLC
1,035,732$51.5B3.10%
7
XLFIHealth Care Select Sector SPDR
400,000$46.7B2.81%Put
8
Checkmate Pharmaceuticals Inc
3,606,707$43.8B2.63%
9
JAZZJazz Pharmaceuticals PLC
255,928$42.1B2.53%
10
INZYInozyme Pharma, Inc.
2,028,308$40.2B2.41%
11
UTHUnited Therapeutics Corp
215,054$36.0B2.16%
12
LLYEli Lilly and Co
180,501$33.7B2.03%
13
Nucana Biomed Ltd
5,599,999$27.9B1.68%
14
MRUSMerus N.V.
1,311,039$27.4B1.65%
15
GRTXGalera Therapeutics, Inc
3,083,712$27.2B1.64%
16
NXTCNextcure, Inc
2,671,856$26.7B1.61%
17
AFWAlign Technology Inc
45,500$24.6B1.48%
18
XLRNAcceleron Pharma Inc
178,538$24.2B1.46%
19
RETAEURReata Pharmaceuticals Inc
238,520$23.8B1.43%
20
MRTXEURMirati Therapeutics Inc
138,030$23.6B1.42%
21
ITCIEURIntra-Cellular Therapies Inc
655,001$22.2B1.34%
22
PTCTPTC Therapeutics Inc
466,840$22.1B1.33%
23
IM8NInsmed Inc
618,950$21.1B1.27%
24
Akouos, Inc
1,515,074$21.0B1.26%
25
GILDGilead Sciences Inc
300,000$19.4B1.17%Call
26
EX9Exelixis Inc
839,181$19.0B1.14%
27
PTGXProtagonist Therapeutics Inc
654,900$17.0B1.02%
28
ObsEva SA
4,749,623$15.4B0.93%
29
QUREUniqure NV
427,122$14.4B0.87%
30
RGNXRegenxbio Inc
361,735$12.3B0.74%
31
HZNPHorizon Therapeutics PLC
133,997$12.3B0.74%
32
Nucana Biomed Ltd
2,400,000$12.0B0.72%
33
VRTXVertex Pharmaceuticals Inc
45,700$9.8B0.59%
34
DC4Dexcom Inc
27,000$9.7B0.58%
35
AMGNAmgen Inc
38,868$9.7B0.58%
36
AGENEURAgenus Inc
3,478,201$9.5B0.57%
37
MIRMMirum Pharmaceuticals Inc
476,401$9.4B0.57%
38
Athira Pharma, Inc.
509,168$9.4B0.56%
39
CCXIEURChemoCentryx Inc
179,999$9.2B0.55%
40
CYTKCytokinetics Inc
389,720$9.1B0.54%
41
ChemoCentryx Inc
150,000$7.7B0.46%Put
42
TCR2 Therapeutics Inc
336,682$7.4B0.45%
43
AMRNAmarin Corp
1,170,584$7.3B0.44%
44
SNDXSyndax Pharmaceuticals Inc
298,644$6.7B0.40%
45
CHRSCoherus BioSciences
434,555$6.3B0.38%
46
ARNAEURArena Pharmaceuticals Inc
91,448$6.3B0.38%
47
MRNS*Marinus Pharmaceuticals Inc
370,351$5.7B0.34%
48
JNCEEURJounce Therapeutics Inc
511,822$5.3B0.32%
49
PODDInsulet Corp
17,500$4.6B0.27%
50
FATEFate Therapeutics Inc
54,795$4.5B0.27%
51
REPLReplimune Group Inc
142,209$4.3B0.26%
52
IMTXImmatics NV
385,099$4.3B0.26%
53
ALGSAligos Therapeutics Inc
185,532$4.2B0.25%
54
Aptose Biosciences Inc
696,928$4.2B0.25%
55
HRTXHeron Therapeutics Inc
250,000$4.1B0.24%Call
56
BCRXBioCryst Pharmaceuticals Inc
378,774$3.9B0.23%
57
YB4PSavara Inc
1,737,450$3.6B0.22%
58
PBYIPuma Biotechnology Inc
344,917$3.4B0.20%
59
OTICEUROtonomy Inc
1,251,256$3.2B0.19%
60
KURAKura Oncology Inc
83,164$2.4B0.14%
61
MGNXMacroGenics Inc
73,201$2.3B0.14%
62
Synlogic Inc.
574,972$2.1B0.12%
63
Calithera Biosciences Inc
757,533$1.8B0.11%
64
PDSBPDS Biotechnology Corporation
142,635$649.0M0.04%