Siren, L.L.C. Q3 2024 Filing
Filed November 13, 2024
Portfolio Value
$2.0T
Holdings
110
Report Date
Q3 2024
Filing Type
13F-HR
All Holdings (110 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | KYMRKymera Therapeutics Inc | 2,969,733 | $140.6B | 7.03% | |
| 2 | ONCBeigene Ltd | 563,314 | $126.5B | 6.32% | |
| 3 | SRRKScholar Rock Holding Corp | 11,259,438 | $90.2B | 4.51% | |
| 4 | BCAXBicara Therapeutics Inc | 3,072,827 | $78.3B | 3.91% | |
| 5 | ARGXArgenx SE | 143,647 | $77.9B | 3.89% | |
| 6 | CRNXCrinetics Pharmaceuticals Inc | 1,309,652 | $66.9B | 3.35% | |
| 7 | RNAAvidity Biosciences Inc | 1,440,736 | $66.2B | 3.31% | |
| 8 | APLSApellis Pharmaceuticals Inc | 2,167,224 | $62.5B | 3.12% | |
| 9 | LXRXLexicon Pharmaceuticals Inc | 38,918,903 | $61.1B | 3.05% | |
| 10 | 1K0IGM Biosciences Inc | 3,330,422 | $55.1B | 2.75% | |
| 11 | CNTACentessa Pharmaceuticals PLC | 3,258,677 | $52.1B | 2.60% | |
| 12 | ASNDAscendis Pharma A/S | 347,921 | $51.9B | 2.60% | |
| 13 | SLNSilence Therapeutics PLC | 2,831,770 | $51.5B | 2.57% | |
| 14 | ARWRArrowhead Pharmaceuticals Inc | 2,458,778 | $47.6B | 2.38% | |
| 15 | WVEWAVE Life Sciences Ltd | 5,721,172 | $46.9B | 2.35% | |
| 16 | SWTXSpringWorks Therapeutics Inc | 1,377,701 | $44.1B | 2.21% | |
| 17 | DYNDyne Therapeutics Inc | 1,134,664 | $40.8B | 2.04% | |
| 18 | VERAVera Therapeutics Inc | 837,928 | $37.0B | 1.85% | |
| 19 | NMRANeumora Therapeutics Inc | 2,606,571 | $34.4B | 1.72% | |
| 20 | PCVXVaxcyte Inc | 299,991 | $34.3B | 1.71% | |
| 21 | RVMDRevolution Medicines Inc | 753,601 | $34.2B | 1.71% | |
| 22 | MRUSMerus NV | 682,201 | $34.1B | 1.70% | |
| 23 | TBLATaboola.com Ltd | 9,969,495 | $33.5B | 1.67% | |
| 24 | —Longboard Pharmaceuticals Inc | 903,227 | $30.1B | 1.50% | |
| 25 | XENEXenon Pharmaceuticals Inc | 743,769 | $29.3B | 1.46% | |
| 26 | CYTKCytokinetics Inc | 525,971 | $27.8B | 1.39% | |
| 27 | KURAKura Oncology Inc | 1,339,942 | $26.2B | 1.31% | |
| 28 | RCUSArcus Biosciences Inc | 1,612,077 | $24.6B | 1.23% | |
| 29 | DNLIDenali Therapeutics Inc | 834,028 | $24.3B | 1.21% | |
| 30 | ERASErasca Inc | 8,857,179 | $24.2B | 1.21% | |
| 31 | CGEMCullinan Therapeutics Inc | 1,211,357 | $20.3B | 1.01% | |
| 32 | TNGXTango Therapeutics Inc | 2,603,897 | $20.1B | 1.00% | |
| 33 | SLDBSolid Biosciences Inc | 2,749,041 | $19.2B | 0.96% | |
| 34 | PRTAProthena Corporation PLC | 1,099,840 | $18.4B | 0.92% | |
| 35 | NAMSNewAmsterdam Pharma Company NV | 920,564 | $15.3B | 0.76% | |
| 36 | BHVNBiohaven Ltd | 283,540 | $14.2B | 0.71% | |
| 37 | KRROKorro Bio Inc | 418,833 | $14.0B | 0.70% | |
| 38 | APLTApplied Therapeutics Inc | 1,633,768 | $13.9B | 0.69% | |
| 39 | GOSSGossamer Bio Inc | 13,488,610 | $13.3B | 0.67% | Call |
| 40 | TILInstil Bio Inc | 192,433 | $13.0B | 0.65% | |
| 41 | EWTXEdgewise Therapeutics Inc | 404,113 | $10.8B | 0.54% | |
| 42 | IOVAIovance Biotherapeutics Inc | 1,106,040 | $10.4B | 0.52% | |
| 43 | ORICOric Pharmaceuticals Inc | 1,007,575 | $10.3B | 0.52% | |
| 44 | ISIIonis Pharmaceuticals Inc | 250,000 | $10.0B | 0.50% | |
| 45 | TSHATaysha Gene Therapies Inc | 4,879,875 | $9.8B | 0.49% | |
| 46 | MSFTMicrosoft Corp | 22,000 | $9.5B | 0.47% | |
| 47 | RNACCartesian Therapeutics Inc | 572,236 | $9.2B | 0.46% | |
| 48 | SLRNACELYRIN Inc | 1,729,665 | $8.5B | 0.43% | |
| 49 | PHATPhathom Pharmaceuticals Inc | 460,753 | $8.3B | 0.42% | |
| 50 | SEERSeer Inc | 4,000,000 | $7.9B | 0.39% | |
| 51 | RAPPRapport Therapeutics Inc | 384,197 | $7.9B | 0.39% | |
| 52 | NGNENeurogene Inc | 175,898 | $7.4B | 0.37% | |
| 53 | GBIOGBXGeneration Bio Co | 2,982,733 | $7.4B | 0.37% | |
| 54 | IHSIHS Holding Limited | 2,357,520 | $7.0B | 0.35% | |
| 55 | CRWDCrowdStrike Holdings Inc | 25,000 | $7.0B | 0.35% | |
| 56 | VIGLVigil Neuroscience Inc | 1,991,038 | $6.8B | 0.34% | |
| 57 | FHTXFoghorn Therapeutics Inc. | 720,720 | $6.7B | 0.34% | |
| 58 | NOWServiceNow Inc | 7,500 | $6.7B | 0.34% | |
| 59 | AMZNAmazon.com Inc | 34,750 | $6.5B | 0.32% | |
| 60 | BIOABIOAGE Labs Inc | 300,000 | $6.2B | 0.31% | |
| 61 | NVDANVIDIA Corp | 48,932 | $5.9B | 0.30% | |
| 62 | SYRSSyros Pharmaceuticals Inc | 2,587,372 | $5.6B | 0.28% | |
| 63 | NVCRNovocure Ltd | 350,884 | $5.5B | 0.27% | |
| 64 | LXEOLexeo Therapeutics Inc | 603,435 | $5.5B | 0.27% | |
| 65 | PDDPDD Holdings Inc | 40,401 | $5.4B | 0.27% | |
| 66 | —Allovir Inc | 6,597,167 | $5.3B | 0.27% | |
| 67 | BDTXBlack Diamond Therapeutics Inc | 1,046,517 | $4.6B | 0.23% | |
| 68 | ANROAlto Neuroscience Inc | 391,406 | $4.5B | 0.22% | |
| 69 | DTDynatrace Inc | 82,729 | $4.4B | 0.22% | |
| 70 | IONQIONQ Inc | 500,000 | $4.4B | 0.22% | |
| 71 | TSMTaiwan Semiconductor Manufacturing Co Ltd | 25,000 | $4.3B | 0.22% | |
| 72 | AGENAgenus Inc | 775,000 | $4.2B | 0.21% | |
| 73 | DDOGDatadog Inc | 32,925 | $3.8B | 0.19% | |
| 74 | ADCTADC Therapeutics SA | 1,163,461 | $3.7B | 0.18% | |
| 75 | SESea Ltd | 37,500 | $3.5B | 0.18% | |
| 76 | OVIDOvid Therapeutics Inc | 2,850,000 | $3.4B | 0.17% | |
| 77 | PYPLPayPal Holdings Inc | 41,000 | $3.2B | 0.16% | Call |
| 78 | RGNXRegenxbio Inc | 284,000 | $3.0B | 0.15% | |
| 79 | N1UANew Oriental Education & Technology Group Inc | 38,500 | $2.9B | 0.15% | |
| 80 | QCOMQualcomm Inc | 15,000 | $2.6B | 0.13% | |
| 81 | HOOKHOOKIPA Pharma Inc | 566,640 | $2.4B | 0.12% | |
| 82 | TRMLTourmaline Bio Inc | 91,426 | $2.4B | 0.12% | |
| 83 | SGMTSagimet Biosciences Inc | 724,771 | $2.0B | 0.10% | |
| 84 | PCORProcore Technologies Inc | 32,300 | $2.0B | 0.10% | |
| 85 | BEKEKe Holdings Inc | 100,000 | $2.0B | 0.10% | |
| 86 | VVisa Inc | 7,000 | $1.9B | 0.10% | |
| 87 | 2JQGritstone bio Inc | 3,318,093 | $1.9B | 0.10% | |
| 88 | GOOGLAlphabet Inc | 11,000 | $1.8B | 0.09% | |
| 89 | OXYOccidental Petroleum Corp | 35,000 | $1.8B | 0.09% | |
| 90 | FROGJfrog Ltd | 61,000 | $1.8B | 0.09% | |
| 91 | —Omega Therapeutics Inc | 1,323,530 | $1.6B | 0.08% | |
| 92 | NTRANatera Inc | 12,594 | $1.6B | 0.08% | |
| 93 | PANWPalo Alto Networks Inc | 4,500 | $1.5B | 0.08% | |
| 94 | ESTCElastic NV | 13,000 | $997.9M | 0.05% | |
| 95 | INTCIntel Corp | 40,000 | $938.4M | 0.05% | |
| 96 | METAMeta Platforms Inc | 1,500 | $858.7M | 0.04% | |
| 97 | KRON1USDKronos Bio Inc | 842,954 | $842.9M | 0.04% | |
| 98 | TERNTerns Pharmaceuticals Inc | 100,000 | $834.0M | 0.04% | |
| 99 | RBRKRubrik Inc | 25,000 | $803.8M | 0.04% | |
| 100 | 698Achilles Therapeutics PLC | 755,375 | $770.5M | 0.04% |
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