Palo Alto Investors LP Q3 2025 Filing

Filed November 14, 2025

Portfolio Value

$540.4B

Holdings

44

Report Date

Q3 2025

Filing Type

13F-HR

All Holdings (44 positions)

#StockSharesValue% PortfolioType
1
IM8NINSMED INC
491,805$70.8B13.11%
2
PTCTPTC THERAPEUTICS INC
862,613$52.9B9.80%
3
ACADACADIA PHARMACEUTICALS INC
2,466,684$52.6B9.74%
4
AM6AMICUS THERAPEUTICS INC
5,367,798$42.3B7.83%
5
BMRNBIOMARIN PHARMACEUTICAL INC
754,007$40.8B7.56%
6
BIIBBIOGEN INC
185,661$26.0B4.81%
7
UTHUNITED THERAPEUTICS CORP
58,186$24.4B4.51%
8
ANABANAPTYSBIO INC
673,520$20.6B3.82%
9
IOVAIOVANCE BIOTHERAPEUTICS INC
7,618,132$16.5B3.06%
10
NVCRNOVOCURE LTD
1,256,159$16.2B3.00%
11
DYNDYNE THERAPEUTICS INC
1,262,674$16.0B2.96%
12
IRONDISC MEDICINE INC
224,300$14.8B2.74%
13
ALNYALNYLAM PHARMACEUTICALS INC
32,320$14.7B2.73%
14
GOSSGOSSAMER BIO INC
5,464,349$14.4B2.66%
15
PRTAPROTHENA CORP PLC
1,324,028$12.9B2.39%
16
RAREULTRAGENYX PHARMACEUTICAL IN
369,531$11.1B2.06%
17
AGIOAGIOS PHARMACEUTICALS INC
265,497$10.7B1.97%
18
SNDXSYNDAX PHARMACEUTICALS INC
654,930$10.1B1.86%
19
EHTHEHEALTH INC
1,544,619$6.7B1.23%
20
DNLIDENALI THERAPEUTICS INC
408,006$5.9B1.10%
21
AFWALIGN TECHNOLOGY INC
45,735$5.7B1.06%
22
ALKSALKERMES PLC
183,938$5.5B1.02%
23
RNAAVIDITY BIOSCIENCES INC
109,831$4.8B0.89%
24
MIRMMIRUM PHARMACEUTICALS INC
64,700$4.7B0.88%
25
CDNACAREDX INC
316,204$4.6B0.85%
26
TSHATAYSHA GENE THERAPIES INC
1,246,033$4.1B0.75%
27
NUVBNUVATION BIO INC
1,020,547$3.8B0.70%
28
ACRSACLARIS THERAPEUTICS INC
1,566,840$3.0B0.55%
29
CRSPCRISPR THERAPEUTICS AG
41,226$2.7B0.49%
30
TVTXTRAVERE THERAPEUTICS INC
110,719$2.6B0.49%
31
EWEDWARDS LIFESCIENCES CORP
33,640$2.6B0.48%
32
NBIXNEUROCRINE BIOSCIENCES INC
18,117$2.5B0.47%
33
STOKSTOKE THERAPEUTICS INC
105,427$2.5B0.46%
34
PYXSPYXIS ONCOLOGY INC
1,037,421$2.3B0.43%
35
BNTXBIONTECH SE-ADR
19,614$1.9B0.36%
36
BCYCBICYCLE THERAPEUTICS PLC-ADR
221,071$1.7B0.32%
37
ALDXALDEYRA THERAPEUTICS INC
225,465$1.2B0.22%
38
HUMHUMANA INC
3,985$1.0B0.19%
39
ORKAORUKA THERAPEUTICS INC
59,985$791.3M0.15%
40
ABEOABEONA THERAPEUTICS INC
108,865$574.8M0.11%
41
URGNUROGEN PHARMA LTD
24,500$488.8M0.09%
42
PRQRPROQR THERAPEUTICS NV
188,807$402.2M0.07%
43
AKTXAKARI THERAPEUTICS PLC-ADR
146,024$147.5M0.03%
44
GBIOGBXGENERATION BIO CO
15,047$92.1M0.02%