Palo Alto Investors LP Q2 2025 Filing

Filed August 14, 2025

Portfolio Value

$470.0B

Holdings

45

Report Date

Q2 2025

Filing Type

13F-HR

All Holdings (45 positions)

#StockSharesValue% PortfolioType
1
IM8NINSMED INC
865,113$87.1B18.52%
2
ACADACADIA PHARMACEUTICALS INC
2,563,209$55.3B11.76%
3
BMRNBIOMARIN PHARMACEUTICAL INC
840,470$46.2B9.83%
4
AM6AMICUS THERAPEUTICS INC
5,610,513$32.1B6.84%
5
UTHUNITED THERAPEUTICS CORP
95,482$27.4B5.84%
6
BIIBBIOGEN INC
205,759$25.8B5.50%
7
ALNYALNYLAM PHARMACEUTICALS INC
75,535$24.6B5.24%
8
PTCTPTC THERAPEUTICS INC
406,469$19.9B4.22%
9
ANABANAPTYSBIO INC
812,821$18.0B3.84%
10
NVCRNOVOCURE LTD
962,396$17.1B3.64%
11
STAASTAAR SURGICAL CO
791,879$13.3B2.83%
12
AGIOAGIOS PHARMACEUTICALS INC
268,783$8.9B1.90%
13
PRTAPROTHENA CORP PLC
1,274,753$7.7B1.65%
14
IRONDISC MEDICINE INC
145,691$7.7B1.64%
15
AFWALIGN TECHNOLOGY INC
37,772$7.2B1.52%
16
GOSSGOSSAMER BIO INC
5,739,013$7.1B1.50%
17
EHTHEHEALTH INC
1,577,850$6.9B1.46%
18
ALKSALKERMES PLC
221,021$6.3B1.35%
19
IOVAIOVANCE BIOTHERAPEUTICS INC
3,429,329$5.9B1.25%
20
SNDXSYNDAX PHARMACEUTICALS INC
444,367$4.2B0.89%
21
RNAAVIDITY BIOSCIENCES INC
118,886$3.4B0.72%
22
DNLIDENALI THERAPEUTICS INC
239,809$3.4B0.71%
23
MIRMMIRUM PHARMACEUTICALS INC
64,700$3.3B0.70%
24
EWEDWARDS LIFESCIENCES CORP
39,473$3.1B0.66%
25
TSHATAYSHA GENE THERAPIES INC
1,246,033$2.9B0.61%
26
BNTXBIONTECH SE-ADR
25,206$2.7B0.57%
27
DYNDYNE THERAPEUTICS INC
264,976$2.5B0.54%
28
CRSPCRISPR THERAPEUTICS AG
44,625$2.2B0.46%
29
ACRSACLARIS THERAPEUTICS INC
1,390,028$2.0B0.42%
30
RAREULTRAGENYX PHARMACEUTICAL IN
48,750$1.8B0.38%
31
BCYCBICYCLE THERAPEUTICS PLC-ADR
248,934$1.7B0.37%
32
NBIXNEUROCRINE BIOSCIENCES INC
13,334$1.7B0.36%
33
TVTXTRAVERE THERAPEUTICS INC
110,719$1.6B0.35%
34
NUVBNUVATION BIO INC
772,652$1.5B0.32%
35
STOKSTOKE THERAPEUTICS INC
125,861$1.4B0.30%
36
PYXSPYXIS ONCOLOGY INC
1,037,421$1.1B0.24%
37
HUMHUMANA INC
3,985$974.3M0.21%
38
ALDXALDEYRA THERAPEUTICS INC
225,465$863.5M0.18%
39
KPTIKARYOPHARM THERAPEUTICS INC
187,911$809.9M0.17%
40
VYNEVYNE THERAPEUTICS INC PIPE
445,434$735.0M0.16%
41
ABEOABEONA THERAPEUTICS INC
108,865$618.4M0.13%
42
ALMSALUMIS INC
143,437$430.3M0.09%
43
URGNUROGEN PHARMA LTD
24,500$335.6M0.07%
44
AKTXAKARI THERAPEUTICS PLC-ADR
146,024$170.8M0.04%
45
GBIOGBXGENERATION BIO CO
150,475$48.2M0.01%