SPHERA FUNDS MANAGEMENT LTD. Q1 2025 Filing

Filed May 15, 2025

Portfolio Value

$434.3B

Holdings

113

Report Date

Q1 2025

Filing Type

13F-HR

All Holdings (113 positions)

#StockSharesValue% PortfolioType
1
TEVATEVA PHARMACEUTICAL INDS LTD
1,572,181$24.2B5.56%
2
TLTISHARES TR
255,100$23.2B5.35%Call
3
SNDXSYNDAX PHARMACEUTICALS INC
1,663,974$20.4B4.71%
4
SNYSANOFI
304,515$16.9B3.89%
5
NVMINOVA LTD
90,697$16.7B3.85%
6
AZNASTRAZENECA PLC
175,060$12.9B2.96%
7
BBIOBRIDGEBIO PHARMA INC
366,608$12.7B2.92%
8
RAREULTRAGENYX PHARMACEUTICAL IN
317,385$11.5B2.65%Call
9
SRPTSAREPTA THERAPEUTICS INC
157,931$10.1B2.32%
10
LLYELI LILLY & CO
11,690$9.7B2.22%
11
TCE2CELLDEX THERAPEUTICS INC NEW
507,829$9.2B2.12%
12
PRAXPRAXIS PRECISION MEDICINES I
240,660$9.1B2.10%Call
13
JNJJOHNSON & JOHNSON
52,831$8.8B2.02%
14
NVONOVO-NORDISK A S
118,080$8.2B1.89%
15
ELDNELEDON PHARMACEUTICALS INC
2,307,119$7.8B1.80%
16
MLYSMINERALYS THERAPEUTICS INC
465,526$7.4B1.70%
17
AMZNAMAZON COM INC
36,607$7.0B1.60%
18
ABBVABBVIE INC
30,256$6.3B1.46%
19
PHVSPHARVARIS N V
383,856$6.0B1.39%
20
HNMORMAT TECHNOLOGIES INC
84,000$5.9B1.37%
21
CYTKCYTOKINETICS INC
144,961$5.8B1.34%
22
METAMETA PLATFORMS INC
9,962$5.7B1.32%
23
NVSNNOVARTIS AG
50,000$5.6B1.28%
24
MRKMERCK & CO INC
59,600$5.3B1.23%
25
ORA 2.5 07/15/27 SEPTORMAT TECHNOLOGIES INC
5,037,000$5.2B1.20%
26
NSYNICE LTD
33,303$5.1B1.18%
27
GSKGSK PLC
130,000$5.0B1.16%
28
SEDGSOLAREDGE TECHNOLOGIES INC
309,216$5.0B1.15%
29
ETNBGBP89BIO INC
618,343$4.5B1.04%
30
MRUSMERUS N V
106,532$4.5B1.03%
31
IMTXIMMATICS N.V
921,111$4.2B0.96%
32
APLSAPELLIS PHARMACEUTICALS INC
181,346$4.0B0.91%
33
MAZEMAZE THERAPEUTICS INC
355,554$3.9B0.90%
34
TVTXTRAVERE THERAPEUTICS INC
200,000$3.6B0.83%
35
YB4PSAVARA INC
1,284,151$3.6B0.82%
36
ARWRARROWHEAD PHARMACEUTICALS IN
277,550$3.5B0.81%
37
DYNDYNE THERAPEUTICS INC
329,262$3.4B0.79%
38
ANNXANNEXON INC
1,764,387$3.4B0.78%
39
JANXJANUX THERAPEUTICS INC
125,840$3.4B0.78%
40
HELPCYBIN INC
527,222$3.3B0.77%
41
IMVTIMMUNOVANT INC
194,638$3.3B0.77%
42
NVDANVIDIA CORPORATION
29,605$3.2B0.74%
43
RZLTREZOLUTE INC
1,081,447$3.1B0.72%
44
RNAAVIDITY BIOSCIENCES INC
106,000$3.1B0.72%
45
AMGNAMGEN INC
10,000$3.1B0.72%
46
BIIBBIOGEN INC
22,738$3.1B0.72%
47
ACOGALPHA COGNITION INC
596,992$3.0B0.70%
48
VIGLVIGIL NEUROSCIENCE INC
1,604,429$2.9B0.66%
49
NTLAINTELLIA THERAPEUTICS INC
381,080$2.7B0.62%
50
DAWNDAY ONE BIOPHARMACEUTICALS I
334,987$2.7B0.61%
51
AMATAPPLIED MATLS INC
18,000$2.6B0.60%
52
SRRKSCHOLAR ROCK HLDG CORP
78,193$2.5B0.58%
53
CRMSALESFORCE INC
9,100$2.4B0.56%
54
BHVNBIOHAVEN LTD
99,784$2.4B0.55%
55
ENGNENGENE HOLDINGS INC
528,365$2.4B0.55%
56
SKYESKYE BIOSCIENCE INC
1,476,353$2.3B0.54%
57
WDAYWORKDAY INC
10,000$2.3B0.54%
58
SWTXSPRINGWORKS THERAPEUTICS INC
52,009$2.3B0.53%
59
PFEPFIZER INC
90,000$2.3B0.53%
60
KURAKURA ONCOLOGY INC
343,522$2.3B0.52%
61
ELVNENLIVEN THERAPEUTICS INC
111,743$2.2B0.51%
62
TSEMTOWER SEMICONDUCTOR LTD
61,549$2.2B0.51%
63
UBERUBER TECHNOLOGIES INC
30,000$2.2B0.50%
64
GOOGALPHABET INC
13,500$2.1B0.49%
65
VKTXVIKING THERAPEUTICS INC
83,270$2.0B0.46%
66
COGTCOGENT BIOSCIENCES INC
335,024$2.0B0.46%
67
VTGNVISTAGEN THERAPEUTICS INC
790,550$2.0B0.46%
68
AVGOBROADCOM INC
11,695$2.0B0.45%
69
ISIIONIS PHARMACEUTICALS INC
63,821$1.9B0.44%
70
NKENIKE INC
30,050$1.9B0.44%
71
CHKPCHECK POINT SOFTWARE TECH LT
8,334$1.9B0.44%
72
RCKTROCKET PHARMACEUTICALS INC
271,792$1.8B0.42%
73
MSFTMICROSOFT CORP
4,592$1.7B0.40%
74
NTRNUTRIEN LTD
30,894$1.5B0.35%
75
GPCRSTRUCTURE THERAPEUTICS INC
84,000$1.5B0.33%
76
WIXWIX COM LTD
8,800$1.4B0.33%
77
FROGJFROG LTD
42,871$1.4B0.32%
78
CAMTCAMTEK LTD
23,086$1.4B0.31%
79
PMNEURPROMIS NEUROSCIENCES INC
1,929,297$1.3B0.31%
80
SHLTSHL TELEMEDICINE LTD
632,456$1.3B0.30%
81
ORICORIC PHARMACEUTICALS INC
234,834$1.3B0.30%
82
CEVACEVA INC
48,920$1.3B0.29%
83
BMYBRISTOL-MYERS SQUIBB CO
20,000$1.2B0.28%
84
VTYXVENTYX BIOSCIENCES INC
1,012,749$1.2B0.27%
85
NNDMNANO DIMENSION LTD
717,518$1.1B0.26%
86
INZYINOZYME PHARMA INC
1,191,140$1.1B0.25%
87
OTLKOUTLOOK THERAPEUTICS INC
857,142$1.0B0.24%
88
CATBUSDASTRIA THERAPEUTICS INC
189,800$1.0B0.23%
89
CMMBCHEMOMAB THERAPEUTICS LTD
900,428$981.5M0.23%
90
CATXPERSPECTIVE THERAPEUTICS INC
460,247$980.3M0.23%
91
MRVLMARVELL TECHNOLOGY INC
15,070$927.9M0.21%
92
ARVNARVINAS INC
125,000$877.5M0.20%
93
XENEXENON PHARMACEUTICALS INC
26,097$875.6M0.20%
94
PERIPERION NETWORK LTD
102,612$835.3M0.19%
95
RGLSREGULUS THERAPEUTICS INC
452,845$792.5M0.18%
96
LRMRLARIMAR THERAPEUTICS INC
366,304$787.6M0.18%
97
CRVSCORVUS PHARMACEUTICALS INC
205,859$654.6M0.15%
98
HOWLWEREWOLF THERAPEUTICS INC
626,810$609.4M0.14%
99
VIRVIR BIOTECHNOLOGY INC
90,855$588.7M0.14%
100
APREAPREA THERAPEUTICS INC
270,000$550.8M0.13%
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