Sofinnova Investments, Inc. Q3 2019 Filing

Filed November 14, 2019

Portfolio Value

$1.1T

Holdings

71

Report Date

Q3 2019

Filing Type

13F-HR

All Holdings (71 positions)

#StockSharesValue% PortfolioType
1
ASNDAscendis Pharma A/S
1,109,874$106.9B9.67%
2
NTRANatera
3,100,560$101.7B9.20%
3
AMRNAmarin
5,208,305$79.0B7.14%
4
NXTCNextcure, Inc
2,521,856$77.8B7.03%
5
YMABUSDY-mAbs Therapeutics, Inc
2,104,278$54.8B4.96%
6
Spark Therapeutics
481,270$46.7B4.22%
7
Principia Biopharma
1,417,258$40.0B3.62%
8
ObsEva SA
4,749,623$39.6B3.58%
9
CHRSCoherus BioSciences
1,933,221$39.2B3.54%
10
MRUSMerus N.V.
1,961,039$34.9B3.16%
11
KRTXKaruna Therapeutics, Inc.
1,729,352$28.2B2.55%
12
Health Care Select Sector SPDR
300,000$27.0B2.44%Put
13
Audentes Therapeutics
933,640$26.2B2.37%
14
BMYBristol-Myers Squibb Co
478,349$24.3B2.19%
15
Allergan plc
134,433$22.6B2.05%
16
VRTXVertex Pharmaceuticals Inc
121,690$20.6B1.86%
17
AMGNAmgen Inc
92,300$17.9B1.61%
18
Nucana Biomed Ltd
2,400,000$17.4B1.57%
19
NBIXNeurocrine Biosciences Inc
191,679$17.3B1.56%
20
Nucana Biomed Ltd
2,266,666$16.4B1.48%
21
XLRNAcceleron Pharma Inc
408,262$16.1B1.46%
22
UTHUnited Therapeutics Corp
194,014$15.5B1.40%
23
PFEPfizer Inc
410,607$14.8B1.33%
24
RETAEURReata Pharmaceuticals Inc
148,669$11.9B1.08%
25
Reata Pharmaceuticals Inc
148,600$11.9B1.08%Put
26
ITRMIterum Therapeutics
1,726,514$10.0B0.90%
27
HALOHalozyme Therapeutics Inc
636,167$9.9B0.89%
28
TGTXTG Therapeutics Inc
1,733,628$9.7B0.88%
29
PTCTPTC Therapeutics Inc
287,245$9.7B0.88%
30
Chiasma
1,630,221$8.1B0.73%
31
SRPTSarepta Therapeutics Inc
106,414$8.0B0.72%
32
KNSAKiniksa Pharmaceuticals, Ltd
922,700$7.9B0.71%
33
MGNXMacroGenics Inc
581,554$7.4B0.67%
34
Aimmune Therapeutics Inc
346,770$7.3B0.66%
35
Entasis Therapeutics Holdings Inc.
1,180,178$7.0B0.64%
36
Kadmon Holdings Inc
2,609,758$6.6B0.59%
37
Dermira Inc
990,168$6.3B0.57%
38
ONCBeigene Ltd
50,000$6.1B0.55%Call
39
MyoKardia Inc
113,926$5.9B0.54%
40
FATEFate Therapeutics Inc
381,600$5.9B0.54%
41
AM6Amicus Therapeutics Inc
722,974$5.8B0.52%
42
BMRNBiomarin Pharmaceutical Inc
84,896$5.7B0.52%
43
Dicerna Pharmaceuticals Inc
342,755$4.9B0.45%
44
AKBAAkebia Therapeutics Inc
1,227,191$4.8B0.43%
45
Zymeworks Inc
188,438$4.7B0.42%
46
HRTXHeron Therapeutics Inc
227,002$4.2B0.38%Call
47
XBITXBiotech Inc
358,663$3.8B0.34%
48
Foamix Pharmaceuticals Ltd
1,199,254$3.6B0.33%
49
OTICEUROtonomy Inc
1,437,965$3.4B0.31%
50
ORTXUSDOrchard Therapeutics PLC
283,406$3.4B0.30%
51
Forty Seven Inc
519,298$3.3B0.30%
52
Calithera Biosciences Inc
964,852$3.0B0.27%
53
ArQule Inc
393,387$2.8B0.25%
54
FIXXEURHomology Medicines Inc
146,297$2.6B0.24%
55
CYTKCytokinetics Inc
210,992$2.4B0.22%
56
MRTXEURMirati Therapeutics Inc
30,800$2.4B0.22%
57
ACRSAclaris Therapeutics
1,911,573$2.1B0.19%
58
KALAKala Pharmaceuticals Inc
478,206$1.8B0.16%
59
SNDXSyndax Pharmaceuticals Inc
243,150$1.8B0.16%
60
AFWAlign Technology Inc
10,000$1.8B0.16%
61
Portola Pharmaceuticals Inc
59,191$1.6B0.14%
62
APLTApplied Therapeutics Inc
142,004$1.6B0.14%
63
SNDXSyndax Pharmaceuticals Inc
200,000$1.5B0.14%Put
64
BCRXBioCryst Pharmaceuticals Inc
516,734$1.5B0.13%
65
YB4PSavara Inc
527,318$1.4B0.13%
66
Synlogic Inc.
574,972$1.3B0.12%
67
APLSApellis Pharmaceuticals, Inc
49,580$1.2B0.11%
68
HRTXHeron Therapeutics Inc
53,800$995.0M0.09%Call
69
Sunesis Pharmaceuticals Inc
1,133,947$816.0M0.07%
70
SNDXSyndax Pharmaceuticals Inc
100,000$746.0M0.07%Call
71
PDSBPDS Biotechnology Corporation
142,635$482.0M0.04%