ORBIMED ADVISORS LLC Q4 2021 Filing
Filed February 14, 2022
Portfolio Value
$7.8B
Holdings
158
Report Date
Q4 2021
Filing Type
13F-HR
All Holdings (158 positions)
| # | Stock | Shares | Value | % Portfolio | Type |
|---|---|---|---|---|---|
| 1 | SWTXSPRINGWORKS THERAPEUTICS INC | 6,028,307 | $373.6B | 4803.45% | |
| 2 | BMYBRISTOL-MYERS SQUIBB CO | 4,339,800 | $270.6B | 3478.67% | |
| 3 | HZNPHORIZON THERAPEUTICS PUB L | 2,500,055 | $269.4B | 3463.49% | |
| 4 | BSXBOSTON SCIENTIFIC CORP | 5,552,300 | $235.9B | 3032.25% | |
| 5 | —THESEUS PHARMACEUTICALS INC | 16,838,668 | $213.5B | 2744.94% | |
| 6 | EWTXEDGEWISE THERAPEUTICS INC | 13,944,680 | $213.1B | 2739.30% | |
| 7 | MRTXEURMIRATI THERAPEUTICS INC | 1,426,400 | $209.2B | 2689.98% | |
| 8 | PMVPPMV PHARMACEUTICALS INC | 7,330,423 | $169.3B | 2176.95% | |
| 9 | PFEPFIZER INC | 2,615,400 | $154.4B | 1985.47% | |
| 10 | HUMHUMANA INC | 318,300 | $147.6B | 1898.15% | |
| 11 | ABBVABBVIE INC | 1,068,800 | $144.7B | 1860.47% | |
| 12 | VRTXVERTEX PHARMACEUTICALS INC | 658,100 | $144.5B | 1857.94% | |
| 13 | EWEDWARDS LIFESCIENCES CORP | 1,076,200 | $139.4B | 1792.41% | |
| 14 | MRKMERCK & CO INC | 1,779,300 | $136.4B | 1753.12% | |
| 15 | UNHUNITEDHEALTH GROUP INC | 271,000 | $136.1B | 1749.45% | |
| 16 | ISRGINTUITIVE SURGICAL INC | 373,800 | $134.3B | 1726.64% | |
| 17 | NTRANATERA INC | 1,413,985 | $132.1B | 1697.66% | |
| 18 | TORCEURADICET BIO INC | 7,447,141 | $130.3B | 1674.50% | |
| 19 | ARQTARCUTIS BIOTHERAPEUTICS INC | 6,073,850 | $126.0B | 1619.50% | |
| 20 | PRLDPRELUDE THERAPEUTICS INC | 10,039,691 | $125.0B | 1606.93% | |
| 21 | SYKSTRYKER CORPORATION | 465,300 | $124.4B | 1599.69% | |
| 22 | GHGUARDANT HEALTH INC | 1,227,400 | $122.8B | 1578.27% | |
| 23 | IOVAIOVANCE BIOTHERAPEUTICS INC | 6,337,700 | $121.0B | 1555.41% | |
| 24 | XBISPDR SER TR | 1,009,700 | $113.0B | 1453.32% | |
| 25 | SGENUSDSEAGEN INC | 655,600 | $101.4B | 1303.04% | |
| 26 | —TURNING POINT THERAPEUTICS I | 2,106,450 | $100.5B | 1291.75% | |
| 27 | HCAHCA HEALTHCARE INC | 389,500 | $100.1B | 1286.50% | |
| 28 | 1T7TRICIDA INC | 10,280,947 | $98.3B | 1263.57% | |
| 29 | KROSKEROS THERAPEUTICS INC | 1,679,417 | $98.3B | 1263.27% | |
| 30 | CRNXCRINETICS PHARMACEUTICALS IN | 3,196,876 | $90.8B | 1167.62% | |
| 31 | MGTXMEIRAGTX HLDGS PLC | 3,727,466 | $88.5B | 1137.63% | |
| 32 | DC4DEXCOM INC | 152,900 | $82.1B | 1055.48% | |
| 33 | NBIXNEUROCRINE BIOSCIENCES INC | 931,915 | $79.4B | 1020.40% | |
| 34 | IMAIKENA ONCOLOGY INC | 6,215,466 | $77.9B | 1002.02% | |
| 35 | BMRNBIOMARIN PHARMACEUTICAL INC | 860,880 | $76.1B | 977.82% | |
| 36 | SVASINOVAC BIOTECH LTD | 2,839,500 | $72.7B | 934.63% | |
| 37 | ZBHZIMMER BIOMET HOLDINGS INC | 564,300 | $71.7B | 921.64% | |
| 38 | IMAPRELUDE THERAPEUTICS INC | 5,680,186 | $70.7B | 909.15% | |
| 39 | RPTXREPARE THERAPEUTICS INC | 3,322,488 | $70.1B | 900.83% | |
| 40 | CMPXCOMPASS THERAPEUTICS INC | 21,642,975 | $68.6B | 882.03% | |
| 41 | —KINNATE BIOPHARMA INC | 3,847,929 | $68.2B | 876.59% | |
| 42 | TBPHTHERAVANCE BIOPHARMA INC | 5,974,535 | $66.0B | 848.74% | |
| 43 | TMOTHERMO FISHER SCIENTIFIC INC | 94,700 | $63.2B | 812.35% | |
| 44 | ABCLABCELLERA BIOLOGICS INC | 4,180,768 | $59.8B | 768.60% | |
| 45 | SPRYSILVERBACK THERAPEUTICS INC | 8,740,887 | $58.2B | 748.40% | |
| 46 | NVLSEURALPINE IMMUNE SCIENCES INC | 4,081,592 | $56.5B | 726.75% | |
| 47 | JANXJANUX THERAPEUTICS INC | 2,836,386 | $56.0B | 719.45% | |
| 48 | BIIBBIOGEN INC | 230,200 | $55.2B | 710.04% | |
| 49 | SIBNSI-BONE INC | 2,305,300 | $51.2B | 658.24% | |
| 50 | ETNBGBP89BIO INC | 3,729,442 | $48.7B | 626.65% | |
| 51 | GRCLGRACELL BIOTECHNOLOGIES INC | 7,884,870 | $47.6B | 612.27% | |
| 52 | PASGPASSAGE BIO INC | 6,962,899 | $44.2B | 568.42% | |
| 53 | SNDXSYNDAX PHARMACEUTICALS INC | 1,981,300 | $43.4B | 557.58% | |
| 54 | OSH3EUROAK STR HEALTH INC | 1,290,300 | $42.8B | 549.74% | |
| 55 | XTNTXTANT MED HLDGS INC | 72,873,494 | $40.8B | 524.64% | |
| 56 | NPCENEUROPACE INC | 4,012,281 | $40.4B | 519.95% | |
| 57 | GLPGGALAPAGOS NV | 717,257 | $39.5B | 508.35% | |
| 58 | TELATELA BIO INC | 3,027,542 | $38.8B | 498.21% | |
| 59 | VRNAVERONA PHARMA PLC | 5,694,841 | $38.3B | 491.99% | |
| 60 | —IKENA ONCOLOGY INC | 2,933,941 | $36.8B | 473.00% | |
| 61 | SEMSELECT MED HLDGS CORP | 1,233,600 | $36.3B | 466.26% | |
| 62 | IVVDADAGIO THERAPEUTICS INC | 4,983,500 | $36.2B | 465.13% | |
| 63 | ORICORIC PHARMACEUTICALS INC | 2,337,574 | $34.4B | 441.76% | |
| 64 | NSTGEURNANOSTRING TECHNOLOGIES INC | 807,100 | $34.1B | 438.18% | |
| 65 | GHRSGH RESEARCH PLC | 1,428,732 | $33.3B | 428.52% | |
| 66 | —SIERRA ONCOLOGY INC | 1,477,320 | $32.1B | 412.90% | |
| 67 | CTKBCYTEK BIOSCIENCES INC | 1,923,139 | $31.4B | 403.50% | |
| 68 | IMGNEURIMMUNOGEN INC | 3,868,786 | $28.7B | 369.05% | |
| 69 | MREOMEREO BIOPHARMA GROUP PLC | 17,264,764 | $27.6B | 355.13% | |
| 70 | TERNTERNS PHARMACEUTICALS INC | 3,791,204 | $26.8B | 344.59% | |
| 71 | PCVXVAXCYTE INC | 1,096,700 | $26.1B | 335.41% | |
| 72 | ERASERASCA INC | 1,667,693 | $26.0B | 334.04% | |
| 73 | EVHEVOLENT HEALTH INC | 938,000 | $26.0B | 333.67% | |
| 74 | —VECTIVBIO HLDG AG | 5,223,804 | $25.6B | 329.74% | |
| 75 | VTYXVENTYX BIOSCIENCES INC | 1,289,280 | $25.6B | 329.18% | |
| 76 | VTGNUSDVISTAGEN THERAPEUTICS INC | 12,909,283 | $25.2B | 323.62% | |
| 77 | THCTENET HEALTHCARE CORP | 299,000 | $24.4B | 314.01% | |
| 78 | —SINGULAR GENOMICS SYSTEMS IN | 2,104,359 | $24.3B | 312.74% | |
| 79 | SCPHSCPHARMACEUTICALS INC | 4,797,148 | $24.1B | 309.60% | |
| 80 | JNCEEURJOUNCE THERAPEUTICS INC | 2,859,900 | $23.9B | 307.00% | |
| 81 | 290ACHINOOK THERAPEUTICS INC | 1,418,300 | $23.1B | 297.39% | |
| 82 | —DECIBEL THERAPEUTICS INC | 4,945,192 | $23.0B | 295.62% | |
| 83 | —HARPOON THERAPEUTICS INC | 2,903,508 | $21.9B | 281.82% | |
| 84 | GILDGILEAD SCIENCES INC | 287,600 | $20.9B | 268.47% | |
| 85 | APLTAPPLIED THERAPEUTICS INC | 2,313,681 | $20.7B | 266.21% | |
| 86 | XENEXENON PHARMACEUTICALS INC | 631,000 | $19.7B | 253.42% | |
| 87 | —LOGICBIO THERAPEUTICS INC | 8,466,783 | $19.6B | 251.44% | |
| 88 | GRPHGRAPHITE BIO INC | 1,565,812 | $19.5B | 250.22% | |
| 89 | —MERSANA THERAPEUTICS INC | 2,888,847 | $18.0B | 231.01% | |
| 90 | CMMBCHEMOMAB THERAPEUTICS LTD | 2,578,174 | $17.8B | 228.70% | |
| 91 | DHR 5 04/15/23 BDANAHER CORPORATION | 10,000 | $17.4B | 223.46% | |
| 92 | —CURIS INC | 3,634,800 | $17.3B | 222.43% | |
| 93 | ILMNILLUMINA INC | 45,100 | $17.2B | 220.58% | |
| 94 | —GEMINI THERAPEUTICS INC | 5,826,224 | $17.0B | 217.96% | |
| 95 | MISTMILESTONE PHARMACEUTICALS IN | 2,583,821 | $16.9B | 217.58% | |
| 96 | CRVSCORVUS PHARMACEUTICALS INC | 6,943,654 | $16.7B | 215.13% | |
| 97 | NXTCNEXTCURE INC | 2,711,013 | $16.3B | 209.12% | |
| 98 | TCE2CELLDEX THERAPEUTICS INC NEW | 406,100 | $15.7B | 201.74% | |
| 99 | RXSTRXSIGHT INC | 1,383,500 | $15.6B | 200.09% | |
| 100 | FLBFLUIDIGM CORP DEL | 3,819,348 | $15.0B | 192.48% |
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