| 1 | Vivo Capital, LLC | 1,789,916 | $10.3M | 0.67% | Share |
| 2 | Octagon Capital Advisors LP | 1,000,000 | $5.8M | 0.70% | Share |
| 3 | Nantahala Capital Management, LLC | 939,202 | $5.4M | 0.18% | Share |
| 4 | MILLENNIUM MANAGEMENT LLC | 1,014,843 | $5.0M | 0.00% | Share |
| 5 | GREAT POINT PARTNERS LLC | 796,558 | $4.6M | 1.49% | Share |
| 6 | VANGUARD GROUP INC | 679,646 | $3.9M | 0.00% | Share |
| 7 | Logos Global Management LP | 473,563 | $2.7M | 0.17% | Share |
| 8 | CANTOR FITZGERALD, L. P. | 200,000 | $1.2M | 0.02% | Share |
| 9 | CITADEL ADVISORS LLC | 258,301 | $1.0M | 0.00% | Share |
| 10 | VANGUARD GROUP INC | 101,074 | $583K | 0.00% | Share |
| 11 | Dauntless Investment Group, LLC | 89,415 | $515K | 0.41% | Share |
| 12 | ACUTA CAPITAL PARTNERS, LLC | 59,985 | $346K | 0.23% | Share |
| 13 | Chicago Partners Investment Group LLC | 22,413 | $155K | 0.00% | Share |
| 14 | UBS Group AG | 19,905 | $114K | 0.00% | Share |
| 15 | VANGUARD GROUP INC | 7,867 | $45K | 0.00% | Share |
| 16 | SBI Securities Co., Ltd. | 558 | $3K | 0.00% | Share |
| 17 | TFC Financial Management, Inc. | 300 | $1K | 0.00% | Share |
| 18 | DANSKE BANK A/S | 1 | $0 | 0.00% | Share |
| 19 | Tower Research Capital LLC (TRC) | 1,920 | $0 | 0.00% | Share |
| 20 | BANK OF AMERICA CORP /DE/ | 139 | $0 | 0.00% | Share |
| 21 | BANK OF AMERICA CORP /DE/ | 13 | $0 | 0.00% | Share |
| 22 | OMERS ADMINISTRATION Corp | 78,200 | $0 | 0.00% | Share |
| 23 | BNP PARIBAS FINANCIAL MARKETS | 99,742 | $0 | 0.00% | Share |
| 24 | MORGAN STANLEY | 42,584 | $0 | 0.00% | Share |
| 25 | BlackRock, Inc. | 36,355 | $0 | 0.00% | Share |
| 26 | HARBOUR INVESTMENTS, INC. | 100 | $0 | 0.00% | Share |
| 27 | Quadrature Capital Ltd | 39,114 | $0 | 0.00% | Share |
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 32,007 | $0 | 0.00% | Share |
| 29 | Bogart Wealth, LLC | 6 | $0 | 0.00% | Share |
| 30 | SIMPLEX TRADING, LLC | 1,100 | $0 | 0.00% | Call |
| 31 | Rockefeller Capital Management L.P. | 500 | $0 | 0.00% | Share |
| 32 | XTX Topco Ltd | 35,405 | $0 | 0.00% | Share |
| 33 | BARCLAYS PLC | 80 | $0 | 0.00% | Share |
| 34 | CITIGROUP INC | 228 | $0 | 0.00% | Share |
| 35 | STATE STREET CORP | 65,227 | $0 | 0.00% | Share |
| 36 | JANE STREET GROUP, LLC | 20,900 | $0 | 0.00% | Call |
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 139,283 | $0 | 0.00% | Share |
| 38 | MORGAN STANLEY | 4,000 | $0 | 0.00% | Share |
| 39 | Squarepoint Ops LLC | 55,305 | $0 | 0.00% | Share |
| 40 | NORTHERN TRUST CORP | 35,937 | $0 | 0.00% | Share |
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,300 | $0 | 0.00% | Call |
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,931 | $0 | 0.00% | Share |
| 43 | CITADEL ADVISORS LLC | 10,900 | $0 | 0.00% | Call |