| 1 | ARK Investment Management LLC | 7,559,495 | $239.8M | 1.59% | Share |
| 2 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 5,954,429 | $188.9M | 0.53% | Share |
| 3 | Artisan Partners Limited Partnership | 5,830,205 | $184.0M | 0.28% | Share |
| 4 | EdgePoint Investment Group Inc. | 5,377,991 | $170.6M | 1.40% | Share |
| 5 | VANGUARD GROUP INC | 5,274,441 | $167.3M | 0.00% | Share |
| 6 | STATE STREET CORP | 3,627,818 | $115.0M | 0.00% | Share |
| 7 | BlackRock, Inc. | 2,816,259 | $89.0M | 0.00% | Share |
| 8 | BlackRock, Inc. | 1,982,674 | $62.0M | 0.00% | Share |
| 9 | Sumitomo Mitsui Trust Group, Inc. | 1,902,829 | $60.4M | 0.04% | Share |
| 10 | Amova Asset Management Americas, Inc. | 1,902,829 | $60.3M | 0.70% | Share |
| 11 | Soleus Capital Management, L.P. | 1,861,802 | $59.1M | 2.18% | Share |
| 12 | MILLENNIUM MANAGEMENT LLC | 1,497,746 | $47.0M | 0.02% | Share |
| 13 | GOLDMAN SACHS GROUP INC | 1,499,450 | $47.0M | 0.01% | Share |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 1,265,003 | $40.0M | 0.00% | Share |
| 15 | Invesco Ltd. | 1,181,233 | $37.5M | 0.01% | Share |
| 16 | First Light Asset Management, LLC | 1,140,771 | $36.2M | 2.77% | Share |
| 17 | THRIVENT FINANCIAL FOR LUTHERANS | 950,476 | $30.0M | 0.05% | Share |
| 18 | AMERICAN CENTURY COMPANIES INC | 865,634 | $27.0M | 0.01% | Share |
| 19 | Tao Capital Management LP | 828,815 | $26.3M | 22.63% | Share |
| 20 | DIMENSIONAL FUND ADVISORS LP | 764,022 | $24.0M | 0.01% | Share |
| 21 | NEW YORK STATE COMMON RETIREMENT FUND | 591,180 | $18.0M | 0.02% | Share |
| 22 | BALYASNY ASSET MANAGEMENT L.P. | 579,370 | $18.0M | 0.02% | Share |
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 555,374 | $17.0M | 0.00% | Share |
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 548,392 | $17.0M | 0.00% | Share |
| 25 | WELLINGTON MANAGEMENT GROUP LLP | 567,403 | $17.0M | 0.00% | Share |
| 26 | STEMPOINT CAPITAL LP | 518,355 | $16.4M | 2.82% | Share |
| 27 | BAILLIE GIFFORD & CO | 504,665 | $16.0M | 0.01% | Share |
| 28 | MORGAN STANLEY | 527,539 | $16.0M | 0.00% | Share |
| 29 | JENNISON ASSOCIATES LLC | 486,631 | $15.4M | 0.01% | Share |
| 30 | NORTHERN TRUST CORP | 450,694 | $14.0M | 0.00% | Share |
| 31 | VANGUARD GROUP INC | 413,004 | $13.1M | 0.00% | Share |
| 32 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 420,776 | $13.0M | 0.00% | Share |
| 33 | THRIVENT FINANCIAL FOR LUTHERANS | 410,879 | $13.0M | 0.02% | Share |
| 34 | BNP PARIBAS FINANCIAL MARKETS | 415,609 | $13.0M | 0.01% | Share |
| 35 | UBS Group AG | 407,242 | $12.9M | 0.00% | Share |
| 36 | Blue Water Life Science Advisors, LP | 383,000 | $12.1M | 7.62% | Share |
| 37 | CITIGROUP INC | 399,650 | $12.0M | 0.01% | Share |
| 38 | BlackRock, Inc. | 390,782 | $12.0M | 0.00% | Share |
| 39 | IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 371,552 | $11.8M | 0.81% | Share |
| 40 | BAILLIE GIFFORD & CO | 340,557 | $10.8M | 0.01% | Share |
| 41 | Aberdeen Group plc | 308,116 | $9.8M | 0.02% | Share |
| 42 | BAILLIE GIFFORD & CO | 293,583 | $9.3M | 0.01% | Share |
| 43 | PEREGRINE CAPITAL MANAGEMENT LLC | 288,283 | $9.1M | 0.28% | Share |
| 44 | Nuveen, LLC | 284,199 | $9.0M | 0.00% | Share |
| 45 | OSTERWEIS CAPITAL MANAGEMENT INC | 256,878 | $8.0M | 0.34% | Share |
| 46 | SEI INVESTMENTS CO | 269,645 | $8.0M | 0.01% | Share |
| 47 | SILVERCREST ASSET MANAGEMENT GROUP LLC | 269,093 | $8.0M | 0.05% | Share |
| 48 | UBS Group AG | 250,772 | $8.0M | 0.00% | Share |
| 49 | JUPITER ASSET MANAGEMENT LTD | 243,669 | $7.7M | 0.06% | Share |
| 50 | Pictet Asset Management Holding SA | 222,647 | $7.3M | 0.01% | Share |