Who Owns Spero Therapeutics, Inc. (SPRO)?Hedge Fund & Institutional Holders
Institutional Holders
50
as of Q4 2025
Total Institutional Value
$5.504000207300019e+127T
% of Float Held
—
QoQ Change in Holders
+9 / -7
Price History
SPRO — Biggest New Institutional Buyers This Quarter
| Fund | Action | Shares Added | Value Added |
|---|---|---|---|
| UBS Group AG | Increased | +89K | +$219.1M |
| GSK plc | New Position | +9.2M | +$21.4M |
| Invesco Ltd. | Increased | +3K | +$15.5M |
| Torrey Growth & Income Advisors | Increased | +1K | +$9.3M |
| VANGUARD GROUP INC | Increased | +94K | +$260K |
| Three Seasons Wealth, LLC | New Position | +30K | +$69K |
| GEODE CAPITAL MANAGEMENT, LLC | Increased | +2K | +$1K |
| OMERS ADMINISTRATION Corp | New Position | +131K | +$0 |
| MILLENNIUM MANAGEMENT LLC | New Position | +24K | +$0 |
| CITADEL ADVISORS LLC | New Position | +398K | +$0 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New Position | +294K | +$0 |
| TWO SIGMA ADVISERS, LP | New Position | +217K | +$0 |
| SIMPLEX TRADING, LLC | Increased | +28K | +$0 |
| Tower Research Capital LLC (TRC) | New Position | +7K | +$0 |
| Point72 Asset Management, L.P. | New Position | +44K | +$0 |
SPRO — Institutions Reducing or Closing Positions
| Fund | Action | Shares Sold | Value Sold |
|---|---|---|---|
| Anson Funds Management LP | Decreased | -979K | -$1.6B |
| RENAISSANCE TECHNOLOGIES LLC | Decreased | -173K | -$731.2M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | Closed Position | -151K | -$283.0M |
| NORTHERN TRUST CORP | Decreased | -9K | -$243.7M |
| Cubist Systematic Strategies, LLC | Closed Position | -41K | -$76.8M |
| AMERICAN CENTURY COMPANIES INC | Closed Position | -40K | -$75.6M |
| XTX Topco Ltd | Decreased | -19K | -$63.5M |
| Rangeley Capital, LLC | Closed Position | -30K | -$56.4M |
| GROUP ONE TRADING LLC | Closed Position | -17K | -$31.7M |
| Assenagon Asset Management S.A. | Decreased | -18K | -$26.5M |
| NewEdge Advisors, LLC | Closed Position | -100 | -$188K |
| MORGAN STANLEY | Decreased | -43K | -$80K |
| Informed Momentum Co LLC | Decreased | -64K | -$22K |
| FMR LLC | Closed Position | -550 | -$1K |
| Ionic Capital Management LLC | Decreased | -13K | -$-64K |
Top Institutional Holders(Q4 2025)
SPRO Institutional Ownership History
| Quarter | Holders | Total Value | Change |
|---|---|---|---|
| Q4 2025 | 56 | $11.9B | +11 |
| Q3 2025 | 45 | $14.1B | +7 |
| Q2 2025 | 38 | $21.4B | -1 |
| Q1 2025 | 39 | $12.8B | -11 |
| Q4 2024 | 50 | $11.8B | +7 |
| Q3 2024 | 43 | $4.5B | -3 |
| Q2 2024 | 46 | $5.6B | +1 |
| Q1 2024 | 45 | $12.8B | — |
Similar Stocks by Institutional Ownership
As of Q4 2025, 50 institutional investors hold SPRO (Spero Therapeutics, Inc.). The largest holder is PFIZER INC with $5.5B in shares. This quarter, 9 institutions opened new positions and 7 closed their positions.
Frequently Asked Questions
How many hedge funds own SPRO?
As of Q4 2025, 50 institutional investors report holding SPRO (Spero Therapeutics, Inc.) in their 13F filings.
Who is the largest institutional holder of SPRO?
The largest institutional holder of SPRO is PFIZER INC with $5.5B in shares.
Is institutional ownership of SPRO increasing or decreasing?
This quarter, 9 institutions opened new positions in SPRO and 7 closed their positions.