Who Owns Spruce Biosciences, Inc. (SPRB)?Hedge Fund & Institutional Holders

$57.55-2.35 (-3.92%)HealthcareNASDAQ

Institutional Holders

40

as of Q4 2025

Total Institutional Value

$6.00000050520004e+138T

% of Float Held

QoQ Change in Holders

+14 / -2

Price History

$4.50$49.02$93.55$138.07$182.60Aug 24May 25Mar 26

SPRB — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
CITADEL ADVISORS LLCNew Position+70K+$6.0B
ADAR1 Capital Management, LLCNew Position+58K+$5.1B
Alyeska Investment Group, L.P.New Position+52K+$4.0B
WELLINGTON MANAGEMENT GROUP LLPNew Position+59K+$4.0B
BALYASNY ASSET MANAGEMENT L.P.New Position+40K+$3.0B
ExodusPoint Capital Management, LPNew Position+25K+$2.0B
Quinn Opportunity Partners LLCNew Position+23K+$2.0B
Caligan Partners LPNew Position+21K+$1.8B
Stonepine Capital Management, LLCNew Position+20K+$1.7B
UBS Group AGIncreased+5K+$425.8M
Resolute Capital Asset Partners LLCNew Position+4K+$348.0M
Sound Income Strategies, LLCNew Position+200+$14.0M
Squadron Capital Management LLCNew Position+70K+$6.1M
BOOTHBAY FUND MANAGEMENT, LLCNew Position+48K+$4.0M
Schonfeld Strategic Advisors LLCNew Position+25K+$2.2M

SPRB — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Carlyle Group Inc.Decreased-2.9M-$21.5B
Cable Car Capital, LPClosed Position-27K-$238.7M
OSAIC HOLDINGS, INC.Closed Position-133-$931K

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1CITADEL ADVISORS LLC69,999$6.0B0.00%Share
2ADAR1 Capital Management, LLC58,000$5.1B0.37%Share
3Alyeska Investment Group, L.P.51,671$4.0B0.01%Share
4Carlyle Group Inc.38,620$3.3B0.02%Share
5BALYASNY ASSET MANAGEMENT L.P.40,000$3.0B0.00%Share
6ExodusPoint Capital Management, LP25,271$2.0B0.02%Share
7WELLINGTON MANAGEMENT GROUP LLP27,568$2.0B0.00%Share
8WELLINGTON MANAGEMENT GROUP LLP25,198$2.0B0.00%Share
9Quinn Opportunity Partners LLC22,810$2.0B0.08%Share
10Caligan Partners LP20,514$1.8B0.15%Share
11Stonepine Capital Management, LLC19,742$1.7B1.26%Share
12UBS Group AG4,902$427.0M0.00%Share
13Resolute Capital Asset Partners LLC4,000$348.0M0.17%Share
14Sound Income Strategies, LLC200$14.0M0.00%Share
15Ikarian Capital, LLC121,356$10.6M0.83%Share
16Squadron Capital Management LLC70,000$6.1M2.58%Share
17BOOTHBAY FUND MANAGEMENT, LLC47,933$4.0M0.06%Share
18Schonfeld Strategic Advisors LLC24,767$2.2M0.01%Share
19SUPERSTRING CAPITAL MANAGEMENT LP12,137$1.1M0.57%Share
20CALDWELL SUTTER CAPITAL, INC.13$1.0M0.00%Share
21VANGUARD GROUP INC11,907$1.0M0.00%Share
22BlackRock, Inc.16,938$1.0M0.00%Share
23SkyView Investment Advisors, LLC3,000$261K0.03%Share
24Lion Point Capital, LP1,000$87K0.45%Share
25WELLINGTON MANAGEMENT GROUP LLP3,962$00.00%Share
26WELLINGTON MANAGEMENT GROUP LLP1,834$00.00%Share
27MORGAN STANLEY388$00.00%Share
28BNP PARIBAS FINANCIAL MARKETS2,000$00.00%Share
29GEODE CAPITAL MANAGEMENT, LLC2,618$00.00%Share
30GEODE CAPITAL MANAGEMENT, LLC10,114$00.00%Share
31VANGUARD GROUP INC5,514$00.00%Share
32Tower Research Capital LLC (TRC)1$00.00%Share
33VANGUARD GROUP INC452$00.00%Share
34BANK OF AMERICA CORP /DE/9$00.00%Share
35BANK OF AMERICA CORP /DE/84$00.00%Share
36NORTHERN TRUST CORP2,422$00.00%Share
37JONES FINANCIAL COMPANIES LLLP84$00.00%Share
38ROYAL BANK OF CANADA40$00.00%Share
39STATE STREET CORP6,400$00.00%Share
40WELLINGTON MANAGEMENT GROUP LLP387$00.00%Share

SPRB Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 202532$33.7B+24
Q3 20258$25.1B+5
Q2 20253$72.6M-27
Q1 202530$2.4B+0
Q4 202430$3.7B+4
Q3 202426$9.5B-4
Q2 202430$20.1B-11
Q1 202441$23.4T

Similar Stocks by Institutional Ownership

As of Q4 2025, 40 institutional investors hold SPRB (Spruce Biosciences, Inc.). The largest holder is CITADEL ADVISORS LLC with $6.0B in shares. This quarter, 14 institutions opened new positions and 2 closed their positions.

Frequently Asked Questions

How many hedge funds own SPRB?

As of Q4 2025, 40 institutional investors report holding SPRB (Spruce Biosciences, Inc.) in their 13F filings.

Who is the largest institutional holder of SPRB?

The largest institutional holder of SPRB is CITADEL ADVISORS LLC with $6.0B in shares.

Is institutional ownership of SPRB increasing or decreasing?

This quarter, 14 institutions opened new positions in SPRB and 2 closed their positions.