| 1 | Merck & Co., Inc. | 14,044,943 | $111.8M | 40.47% | Share |
| 2 | Lightspeed Management Company, L.L.C. | 8,160,734 | $65.0M | 4.65% | Share |
| 3 | ARK Investment Management LLC | 7,879,087 | $62.7M | 0.42% | Share |
| 4 | AMERIPRISE FINANCIAL INC | 3,507,345 | $27.0M | 0.01% | Share |
| 5 | Aberdeen Group plc | 3,249,895 | $25.9M | 0.04% | Share |
| 6 | VANGUARD GROUP INC | 2,876,807 | $22.9M | 0.00% | Share |
| 7 | AMERIPRISE FINANCIAL INC | 2,615,607 | $20.0M | 0.00% | Share |
| 8 | BlackRock, Inc. | 2,472,531 | $19.0M | 0.00% | Share |
| 9 | AIGH Capital Management LLC | 2,114,209 | $16.8M | 4.07% | Share |
| 10 | T. Rowe Price Investment Management, Inc. | 1,938,037 | $15.4M | 0.02% | Share |
| 11 | BlackRock, Inc. | 1,848,136 | $14.0M | 0.00% | Share |
| 12 | KENNEDY CAPITAL MANAGEMENT LLC | 1,712,652 | $13.6M | 0.29% | Share |
| 13 | Blue Water Life Science Advisors, LP | 1,676,300 | $13.3M | 8.37% | Share |
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,372,591 | $10.0M | 0.00% | Share |
| 15 | STATE STREET CORP | 1,050,590 | $8.0M | 0.00% | Share |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 1,126,300 | $8.0M | 0.00% | Share |
| 17 | PFM Health Sciences, LP | 805,817 | $6.4M | 0.64% | Share |
| 18 | AIGH Capital Management LLC | 785,791 | $6.3M | 1.51% | Share |
| 19 | DIMENSIONAL FUND ADVISORS LP | 860,367 | $6.0M | 0.00% | Share |
| 20 | NEXT CENTURY GROWTH INVESTORS LLC | 624,363 | $5.0M | 0.35% | Share |
| 21 | HOWLAND CAPITAL MANAGEMENT LLC | 547,115 | $4.4M | 0.17% | Share |
| 22 | Sumitomo Mitsui Trust Group, Inc. | 518,441 | $4.1M | 0.00% | Share |
| 23 | Amova Asset Management Americas, Inc. | 518,441 | $4.1M | 0.05% | Share |
| 24 | BlackRock, Inc. | 526,901 | $4.0M | 0.00% | Share |
| 25 | STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | $3.9M | 0.02% | Share |
| 26 | Portolan Capital Management, LLC | 379,197 | $3.0M | 0.16% | Share |
| 27 | Wellington Shields Capital Management, LLC | 340,000 | $2.7M | 0.39% | Share |
| 28 | VANGUARD GROUP INC | 340,029 | $2.7M | 0.00% | Share |
| 29 | ORACLE INVESTMENT MANAGEMENT INC | 339,343 | $2.7M | 1.61% | Share |
| 30 | UBS Group AG | 301,555 | $2.4M | 0.00% | Share |
| 31 | Wellington Shields & Co., LLC | 292,489 | $2.3M | 0.57% | Share |
| 32 | NANO CAP NEW MILLENNIUM GROWTH FUND L P | 290,000 | $2.3M | 1.97% | Share |
| 33 | IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 267,674 | $2.1M | 0.15% | Share |
| 34 | NORTHERN TRUST CORP | 346,917 | $2.0M | 0.00% | Share |
| 35 | GOLDMAN SACHS GROUP INC | 293,705 | $2.0M | 0.00% | Share |
| 36 | Nuveen, LLC | 308,680 | $2.0M | 0.00% | Share |
| 37 | FIRST MANHATTAN CO. LLC. | 373,822 | $2.0M | 0.01% | Share |
| 38 | TD ASSET MANAGEMENT INC | 271,876 | $2.0M | 0.00% | Share |
| 39 | PERKINS CAPITAL MANAGEMENT INC | 239,000 | $1.9M | 1.51% | Share |
| 40 | Bruce & Co., Inc. | 233,000 | $1.9M | 0.57% | Share |
| 41 | D.A. DAVIDSON & CO. | 145,507 | $1.2M | 0.01% | Share |
| 42 | JANE STREET GROUP, LLC | 169,977 | $1.0M | 0.00% | Share |
| 43 | GEODE CAPITAL MANAGEMENT, LLC | 171,507 | $1.0M | 0.00% | Share |
| 44 | AMERIPRISE FINANCIAL INC | 163,399 | $1.0M | 0.00% | Share |
| 45 | Williams Jones Wealth Management, LLC. | 134,072 | $1.0M | 0.01% | Share |
| 46 | LPL Financial LLC | 132,343 | $1.0M | 0.00% | Share |
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 158,170 | $1.0M | 0.00% | Share |
| 48 | BlackRock, Inc. | 176,205 | $1.0M | 0.00% | Share |
| 49 | BlackRock, Inc. | 165,475 | $1.0M | 0.00% | Share |
| 50 | Green Alpha Advisors, LLC | 68,517 | $545K | 0.50% | Share |