Sofinnova Investments, Inc. Q4 2021 Filing

Filed February 14, 2022

Portfolio Value

$1.7T

Holdings

68

Report Date

Q4 2021

Filing Type

13F-HR

All Holdings (68 positions)

#StockSharesValue% PortfolioType
1
NTRANatera Inc
3,102,960$289.8B16.93%
2
KRTXKaruna Therapeutics, Inc.
1,952,441$255.8B14.94%
3
VERAVera Therapeutics, Inc.
2,914,776$77.9B4.55%
4
RHHBYRoche Holding AG
1,369,011$70.8B4.13%
5
ASNDAscendis Pharma A/S
499,824$67.2B3.93%
6
SPYSPDR S&P 500 ETF Trust
100,000$47.5B2.77%Put
7
AVTEAerovate Therapeutics, Inc.
3,758,686$44.3B2.59%
8
ABBVAbbvie Inc
312,018$42.2B2.47%
9
NDQInvesco QQQ Trust Series 1
100,000$39.8B2.32%Put
10
YMABUSDY-mAbs Therapeutics, Inc
2,194,278$35.6B2.08%
11
IWMiShares Russell 2000 ETF
150,000$33.4B1.95%Put
12
RGNXRegenxbio Inc
1,008,081$33.0B1.93%
13
TVTXTravere Therapeutics Inc
1,040,858$32.3B1.89%
14
UTHUnited Therapeutics Corp
129,754$28.0B1.64%
15
HRTXHeron Therapeutics Inc
2,933,351$26.8B1.56%
16
PTGXProtagonist Therapeutics Inc
782,857$26.8B1.56%Call
17
CCXIEURChemoCentryx Inc
731,222$26.6B1.56%
18
2L9Blueprint Medicines Corp
245,182$26.3B1.53%
19
AFWAlign Technology Inc
38,159$25.1B1.46%
20
HZNPHorizon Therapeutics PLC
221,792$23.9B1.40%
21
GHGuardant Health Inc
232,563$23.3B1.36%
22
XNCRXencor Inc
537,030$21.5B1.26%
23
CYTKCytokinetics Inc
464,366$21.2B1.24%
24
BCRXBioCryst Pharmaceuticals Inc
1,510,473$20.9B1.22%
25
SNDXSyndax Pharmaceuticals Inc
951,226$20.8B1.22%
26
IRTCiRhythm Technologies Inc
168,882$19.9B1.16%
27
DC4Dexcom Inc
32,404$17.4B1.02%
28
INBXUSDInhibrx Inc
368,679$16.1B0.94%
29
NXTCNextcure, Inc
2,671,856$16.0B0.94%
30
GRTXGalera Therapeutics, Inc
3,083,712$14.2B0.83%
31
INZYInozyme Pharma, Inc.
2,028,308$13.8B0.81%
32
IMTXImmatics NV
1,026,623$13.8B0.81%
33
BOLT1EURBolt Biotherapeutics, Inc.
2,754,437$13.5B0.79%
34
OPHTEURIveric Bio Inc
798,789$13.4B0.78%
35
Nucana Plc
5,599,999$13.3B0.78%
36
JNCEEURJounce Therapeutics Inc
1,582,777$13.2B0.77%
37
IMGNEURImmunoGen Inc
1,749,882$13.0B0.76%
38
Akouos, Inc.
1,515,074$12.9B0.75%
39
IM8NInsmed Inc
441,773$12.0B0.70%
40
FULCFulcrum Therapeutics Inc
617,670$10.9B0.64%
41
SRPTSarepta Therapeutics Inc
120,732$10.9B0.64%
42
TCE2Celldex Therapeutics Inc
271,533$10.5B0.61%
43
Checkmate Pharmaceuticals Inc
3,606,707$10.4B0.60%
44
QUREUniqure NV
495,025$10.3B0.60%
45
ObsEva SA
4,749,623$9.5B0.55%
46
VIRVir Biotechnology Inc
200,000$8.4B0.49%Put
47
BMRNBiomarin Pharmaceutical Inc
87,322$7.7B0.45%
48
KURAKura Oncology Inc
544,173$7.6B0.44%Call
49
Zymeworks Inc
392,712$6.4B0.38%
50
AGENEURAgenus Inc
1,961,032$6.3B0.37%
51
Nucana Plc
2,400,000$5.7B0.33%
52
IFRXInflarx NV
1,161,736$5.5B0.32%
53
TORCEURAdicet Bio Inc
310,988$5.4B0.32%
54
PTCTPTC Therapeutics Inc
132,448$5.3B0.31%
55
Sierra Oncology Inc
212,281$4.6B0.27%
56
AXSMAxsome Therapeutics Inc
100,000$3.8B0.22%Put
57
NVCRNovocure Ltd
50,000$3.8B0.22%Call
58
ITCIEURIntra-Cellular Therapies Inc
56,915$3.0B0.17%
59
ICPTUSDIntercept Pharmaceuticals Inc
150,400$2.5B0.14%Call
60
CYTCyteir Therapeutics Inc
179,450$2.0B0.12%
61
MRNS*Marinus Pharmaceuticals Inc
171,338$2.0B0.12%
62
Mink Therapeutics Inc
345,499$1.5B0.09%
63
ALGSAligos Therapeutics Inc
127,791$1.5B0.09%
64
Synlogic Inc.
574,972$1.4B0.08%
65
PDSBPDS Biotechnology Corporation
142,635$1.2B0.07%
66
Fusion Pharmaceuticals Inc
78,066$326.0M0.02%
67
PODDInsulet Corp
1,066$284.0M0.02%
68
EWEdwards Lifesciences Corp
1,406$182.0M0.01%
69
KRTXKaruna Therapeutics Inc
636$83.0M0.00%