Sofinnova Investments, Inc. Q4 2018 Filing

Filed February 14, 2019

Portfolio Value

$767.9B

Holdings

58

Report Date

Q4 2018

Filing Type

13F-HR

All Holdings (58 positions)

#StockSharesValue% PortfolioType
1
ASNDAscendis Pharma A/S
1,498,538$93.9B12.23%
2
AMRNAmarin
5,208,305$70.9B9.23%
3
ObsEva SA
4,749,623$60.1B7.83%
4
Principia Biopharma
2,038,208$55.8B7.27%
5
NTRANatera
3,100,560$43.3B5.64%
6
YMABUSDY-mAbs Therapeutics, Inc
2,104,278$42.8B5.57%
7
Nucana Biomed Ltd
2,266,666$32.9B4.28%
8
MRUSMerus N.V.
1,961,039$27.5B3.58%
9
CHRSCoherus BioSciences
2,868,221$26.0B3.38%
10
KNSAKiniksa Pharmaceuticals, Ltd
922,700$25.9B3.38%
11
Audentes Therapeutics
933,640$19.9B2.59%
12
Spark Therapeutics
481,270$18.8B2.45%
13
SNYSanofi SA
327,175$14.2B1.85%
14
ACRSAclaris Therapeutics
1,911,573$14.1B1.84%
15
GILDGilead Sciences Inc
213,331$13.3B1.74%
16
AZNAstraZeneca PLC
316,328$12.0B1.56%
17
INCYIncyte Corp
188,497$12.0B1.56%
18
BMRNBiomarin Pharmaceutical Inc
140,542$12.0B1.56%
19
TESARO Inc
134,297$10.0B1.30%
20
HRTXHeron Therapeutics Inc
359,713$9.3B1.22%
21
RETAEURReata Pharmaceuticals Inc
157,984$8.9B1.15%
22
ITRMIterum Therapeutics
1,726,514$8.7B1.13%
23
MorphoSys AG
80,536$8.2B1.07%
24
RIGLUSDRigel Pharmaceuticals Inc
3,382,174$7.8B1.01%
25
XNCRXencor Inc
199,682$7.2B0.94%
26
AM6Amicus Therapeutics Inc
674,636$6.5B0.84%
27
YB4PSavara Inc
754,372$5.7B0.74%
28
DCPHEURDeciphera Pharmaceuticals Inc
265,475$5.6B0.73%
29
ICPTUSDIntercept Pharmaceuticals Inc
54,472$5.5B0.72%
30
SRPTSarepta Therapeutics Inc
48,894$5.3B0.69%
31
CLVSEURClovis Oncology Inc
287,769$5.2B0.67%
32
Chiasma
1,630,221$5.1B0.66%
33
Entasis Therapeutics Holdings Inc.
1,180,178$4.8B0.63%
34
NBIXNeurocrine Biosciences Inc
61,500$4.4B0.57%
35
MGNXMacroGenics Inc
332,921$4.2B0.55%
36
Aimmune Therapeutics Inc
175,775$4.2B0.55%
37
Synlogic Inc. (fmrly Mirna)
574,972$4.0B0.52%
38
Dermira Inc
542,224$3.9B0.51%
39
PBYIPuma Biotechnology Inc
190,627$3.9B0.51%
40
FGENEURFibroGen Inc
80,000$3.7B0.48%
41
Biohaven Pharmaceutical Holding Company Ltd
97,445$3.6B0.47%
42
ORTXUSDOrchard Therapeutics PLC
222,618$3.5B0.46%
43
Epizyme Inc
563,655$3.5B0.45%
44
Kadmon Holdings Inc
1,651,172$3.4B0.45%
45
Foamix Pharmaceuticals Ltd
832,293$3.0B0.39%
46
FATEFate Therapeutics Inc
229,813$2.9B0.38%
47
Five Prime Therapeutics Inc
315,344$2.9B0.38%
48
GW Pharmaceuticals PLC
30,000$2.9B0.38%
49
KALAKala Pharmaceuticals Inc
445,516$2.2B0.28%
50
IMGNEURImmunoGen Inc
447,075$2.1B0.28%
51
Osmotica Pharmaceuticals PLC
253,089$2.0B0.26%
52
OTICEUROtonomy Inc
1,023,865$1.9B0.25%
53
ANABAnaptysBio Inc
25,020$1.6B0.21%
54
SNDXSyndax Pharmaceuticals Inc
350,110$1.6B0.20%
55
Conatus Pharmaceuticals Inc
638,197$1.1B0.14%
56
Edge Therapeutics
2,852,711$916.0M0.12%
57
PCRXPacira Pharmaceuticals Inc
16,994$731.0M0.10%
58
APLSApellis Pharmaceuticals, Inc
49,580$654.0M0.09%