Sofinnova Investments, Inc. Q3 2021 Filing

Filed November 15, 2021

Portfolio Value

$1.7T

Holdings

70

Report Date

Q3 2021

Filing Type

13F-HR

All Holdings (70 positions)

#StockSharesValue% PortfolioType
1
NTRANatera Inc
3,102,960$345.8B20.48%
2
KRTXKaruna Therapeutics, Inc.
1,953,077$238.9B14.15%
3
ASNDAscendis Pharma A/S
499,824$79.7B4.72%
4
AVTEAerovate Therapeutics, Inc.
3,758,686$78.9B4.67%
5
AZNAstraZeneca PLC
1,128,272$67.8B4.01%
6
YMABUSDY-mAbs Therapeutics, Inc.
2,194,278$62.6B3.71%
7
VERAVera Therapeutics, Inc.
2,914,776$50.6B2.99%
8
MRKMerck & Co Inc
600,000$45.1B2.67%Call
9
UTHUnited Therapeutics Corp
222,094$41.0B2.43%
10
BOLT1EURBolt Biotherapeutics, Inc.
2,754,437$34.8B2.06%
11
AFWAlign Technology Inc
47,000$31.3B1.85%
12
ABBVAbbvie Inc
272,600$29.4B1.74%
13
GRTXGalera Therapeutics, Inc.
3,083,712$25.0B1.48%
14
HRTXHeron Therapeutics Inc
2,301,179$24.6B1.46%
15
BMYBristol-Myers Squibb Co
400,000$23.7B1.40%Call
16
INZYInozyme Pharma, Inc.
2,028,308$23.5B1.39%
17
DC4Dexcom Inc
37,266$20.4B1.21%
18
2L9Blueprint Medicines Corp
181,860$18.7B1.11%
19
REGNRegeneron Pharmaceuticals
30,000$18.2B1.08%Put
20
NXTCNextcure, Inc
2,671,856$18.0B1.07%
21
Akouos, Inc.
1,515,074$17.6B1.04%
22
UTHRUnited Therapeutics Corp
94,500$17.4B1.03%Put
23
HZNPHorizon Therapeutics Pub L
157,487$17.3B1.02%
24
RETAEURReata Pharmaceuticals Inc
157,488$15.8B0.94%
25
CYTKCytokinetics Inc
426,632$15.2B0.90%
26
ObsEva SA
4,749,623$14.8B0.87%
27
ZTSZoetis Inc
76,000$14.8B0.87%
28
IM8NInsmed Inc
535,120$14.7B0.87%
29
SRPTSarepta Therapeutics, Inc.
157,279$14.5B0.86%
30
Nucana Plc
5,599,999$14.4B0.86%
31
Checkmate Pharmaceuticals Inc
3,606,707$14.3B0.85%
32
KURAKura Oncology Inc
755,121$14.1B0.84%
33
AGENEURAgenus Inc
2,344,410$12.3B0.73%
34
Zymeworks Inc
410,619$11.9B0.71%
35
TVTXTravere Therapeutics Inc
437,280$10.6B0.63%
36
EX9Exelixis Inc
488,414$10.3B0.61%
37
MRTXEURMirati Therapeutics Inc
56,900$10.1B0.60%
38
BIIBBiogen Inc
33,220$9.4B0.56%
39
Kadmon Holdings Inc
1,046,312$9.1B0.54%
40
CCXIEURChemoCentryx Inc
517,708$8.9B0.52%
41
ChemoCentryx Inc
505,800$8.6B0.51%Put
42
PTCTPTC Therapeutics Inc
230,019$8.6B0.51%
43
ITCIEURIntra-Cellular Therapies Inc
227,419$8.5B0.50%
44
ALXOALX Oncology Holdings Inc
107,220$7.9B0.47%
45
SNDXSyndax Pharmaceuticals Inc
413,841$7.9B0.47%
46
TCE2Celldex Therapeutics, Inc.
137,032$7.4B0.44%
47
XLRNAcceleron Pharma Inc
39,589$6.8B0.40%
48
IMTXImmatics N.V
478,216$6.2B0.37%
49
Nucana Plc
2,400,000$6.2B0.37%
50
CTIC1USDCTI BioPharma Corp
2,074,714$6.1B0.36%
51
OPHTEURIveric Bio Inc
357,400$5.8B0.34%
52
AMRNAmarin Corp
1,069,968$5.5B0.32%
53
RGNXRegenxbio Inc
127,593$5.3B0.32%
54
PTGXProtagonist Therapeutics Inc
300,000$5.3B0.31%Call
55
PTGXProtagonist Therapeutics Inc
297,709$5.3B0.31%
56
GHGuardant Health Inc
40,000$5.0B0.30%
57
JNCEEURJounce Therapeutics Inc
637,347$4.7B0.28%
58
Sierra Oncology, Inc.
206,564$4.5B0.27%
59
CYTCyteir Therapeutics, Inc.
246,321$4.3B0.26%
60
Iveric Bio Inc
255,300$4.1B0.25%Put
61
NVCRNovocure Ltd
30,000$3.5B0.21%Call
62
Intercept Pharmaceuticals In
190,000$2.8B0.17%Call
63
QUREUniqure NV
78,742$2.5B0.15%
64
PDSBPDS Biotechnology Corporation
142,635$2.1B0.13%
65
ALGSAligos Therapeutics Inc
124,342$1.9B0.11%
66
MRNS*Marinus Pharmaceuticals Inc
166,711$1.9B0.11%
67
Synlogic Inc.
574,972$1.8B0.10%
68
FULCFulcrum Therapeutics Inc
51,006$1.4B0.09%
69
Fusion Pharmaceuticals Inc
78,066$618.0M0.04%
70
PODDInsulet Corp
1,066$303.0M0.02%