BAKER BROS. ADVISORS LP Q2 2016 Filing

Filed August 15, 2016

Portfolio Value

$9.5B

Holdings

135

Report Date

Q2 2016

Filing Type

13F-HR

All Holdings (135 positions)

#StockSharesValue% PortfolioType
101
Mast Therapeutics, Inc.
3,868,026$1.8B19.06%
102
MediWound Ltd.
226,000$1.8B18.69%
103
AMRNAmarin Corporation plc
801,860$1.7B18.16%
104
QUREuniQure N.V.
230,000$1.7B17.77%
105
ENTAEnanta Pharmaceuticals, Inc.
75,357$1.7B17.43%
106
CytRx Corporation
659,995$1.5B15.43%
107
KPTIEURKaryopharm Therapeutics Inc.
216,990$1.5B15.27%
108
ASMBAssembly Biosciences, Inc.
250,000$1.4B14.55%
109
GW Pharmaceuticals plc
15,000$1.4B14.41%
110
ISIIonis Pharmaceuticals, Inc.
57,140$1.3B13.95%
111
CLLSCellectis S.A.
50,000$1.3B13.94%
112
Immune Design Corp.
148,937$1.2B12.74%
113
DVAXDynavax Technologies Corporation
75,000$1.1B11.47%
114
Tenax Therapeutics, Inc.
420,000$1.1B11.27%
115
SCYXEURSCYNEXIS, Inc.
467,600$1.0B10.64%
116
Affimed N.V.
400,000$992.0M10.40%
117
XLRNAcceleron Pharma Inc.
28,765$977.0M10.24%
118
Palatin Technologies, Inc.
2,050,000$905.0M9.49%
119
ADAPYAdaptimmune Therapeutics plc
100,000$815.0M8.54%
120
ALDXAldeyra Therapeutics, Inc.
142,000$808.0M8.47%
121
Five Prime Therapeutics, Inc.
19,247$796.0M8.35%
122
ALNYAlnylam Pharmaceuticals, Inc.
11,340$629.0M6.59%
123
I9DNArbutus Biopharma Corporation
180,582$628.0M6.58%
124
Ritter Pharmaceuticals, Inc.
400,000$612.0M6.42%
125
Synta Pharmaceuticals Corp.
2,021,728$526.0M5.51%
126
BioDelivery Sciences International, Inc.
210,021$496.0M5.20%
127
Windtree Therapeutics, Inc.
254,973$492.0M5.16%
128
CMRXEURChimerix, Inc.
115,216$453.0M4.75%
129
ProNAi Therapeutics, Inc.
200,000$398.0M4.17%
130
Foundation Medicine, Inc.
20,892$390.0M4.09%
131
Achaogen, Inc.
100,000$379.0M3.97%
132
CCXIEURChemoCentryx, Inc.
49,064$220.0M2.31%
133
La Jolla Pharmaceutical Company
13,746$220.0M2.31%
134
BGMS 6 PERPCyclacel Pharmaceuticals, Inc.
13,253$83.0M0.87%
135
BioTime, Inc.
20,084$9.0M0.09%
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